sk3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61605	SK3 Channel-IN-1
	SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in ot...
T12256	NS8593 hydrochloride	NS8593 HCl	Potassium Channel
	NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .		Potassium Channel
T24111	GSK3i XIII	GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII	GSK-3
	GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.		GSK-3
T15440	GSK376501A		PPAR
	GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.		PPAR
T7195	GSK369796 Dihydrochloride	N-tert-butylisoquine	Potassium Channel , Parasite
	GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM)		Potassium Channel , Parasite
T5491	GSK3179106		c-RET
	GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM		c-RET
T21956	GSK3β inhibitor II		GSK-3
	GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).		GSK-3
T64366	GSK3-IN-4		GSK-3
	GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.		GSK-3
T6059	GSK343		Histone Methyltransferase , Autophagy
	GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases.		Histone Methyltransferase , Autophagy
T15558	GSK319347A		IκB/IKK
	GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.		IκB/IKK
T73270	GSK3-IN-2		GSK-3
	GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.		GSK-3
T5745	GSK3326595	EPZ015938	Histone Methyltransferase
	GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).		Histone Methyltransferase
T15437	GSK3145095		RIP kinase
	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.		RIP kinase
T9573	GSK3685032		DNA Methyltransferase
	GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c...		DNA Methyltransferase
T11500L	GSK3368715 dihydrochloride	EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4...		Histone Methyltransferase
T73331	GSK3-IN-3		Mitophagy , GSK-3
	GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective...		Mitophagy , GSK-3
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T24109	GSK329	GSK 329,GSK-329	Others
	GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury.		Others
T77671	GSK3a-IN-38		GSK-3
	GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.		GSK-3
T27478	GSK3987		Liver X Receptor
	GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.		Liver X Receptor