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NS8593 hydrochloride

NS8593 hydrochloride
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
Catalog No. T12256Cas No. 875755-24-1
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Purity:99.77%
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NS8593 hydrochloride

Catalog No. T12256Cas No. 875755-24-1
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$54In Stock
5 mg$85In Stock
10 mg$162In Stock
25 mg$369In Stock
50 mg$553In Stock
100 mg$796In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Product Introduction

Bioactivity
Description
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
Targets&IC50
SK1:0.42 μM (kd), SK3:0.73 μM (kd), SK2:0.60 μM (kd)
In vitro
It is found that tested in excised patches, the inhibition by NS8593 (compound 14) decreased as the intracellular [Ca2+] is increased and that NS8593 is equipotent when applied from either the intracellular or the extracellular side of the cell membrane.?A HEK293 cell transiently transfected with hSK3 channels is inhibited by 80% upon application of 100 nM apamin and by 75% after application of 300 nM NS8593.
In vivo
NS8593 is able to affect firing pattern and firing rate?of dopaminergic neurons in vivo in C57Bl/6 mice[1].
AliasNS8593 HCl
Chemical Properties
Molecular Weight299.8
FormulaC17H18ClN3
Cas No.875755-24-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (266.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3356 mL16.6778 mL33.3556 mL166.7779 mL
5 mM0.6671 mL3.3356 mL6.6711 mL33.3556 mL
10 mM0.3336 mL1.6678 mL3.3356 mL16.6778 mL
20 mM0.1668 mL0.8339 mL1.6678 mL8.3389 mL
50 mM0.0667 mL0.3336 mL0.6671 mL3.3356 mL
100 mM0.0334 mL0.1668 mL0.3336 mL1.6678 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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