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GSK3145095

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.

Catalog No. T15437Cas No. 1622849-43-7

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Purity:100%

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GSK3145095

Catalog No. T15437Cas No. 1622849-43-7

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$259	In Stock
10 mg	$363	In Stock
25 mg	$583	In Stock
50 mg	$766	In Stock
100 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$252	In Stock

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Product Introduction

Bioactivity

Description	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
Targets&IC50	RIP1 kinase:6.3 nM (IC50)
In vitro	GSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinase-dependent cellular responses.?Highlighting its potential as a novel cancer therapy, the inhibitor was also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures.

Chemical Properties

Molecular Weight	397.38
Formula	C₂₀H₁₇F₂N₅O₂
Cas No.	1622849-43-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 245 mg/mL (616.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5165 mL	12.5824 mL	25.1648 mL	125.8241 mL
5 mM	0.5033 mL	2.5165 mL	5.0330 mL	25.1648 mL
10 mM	0.2516 mL	1.2582 mL	2.5165 mL	12.5824 mL
20 mM	0.1258 mL	0.6291 mL	1.2582 mL	6.2912 mL
50 mM	0.0503 mL	0.2516 mL	0.5033 mL	2.5165 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2582 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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