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GSK3145095

GSK3145095
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
Catalog No. T15437Cas No. 1622849-43-7
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GSK3145095

Catalog No. T15437Cas No. 1622849-43-7
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$259In Stock
10 mg$363In Stock
25 mg$583In Stock
50 mg$766In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$252In Stock
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Product Introduction

Bioactivity
Description
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
Targets&IC50
RIP1 kinase:6.3 nM (IC50)
In vitro
GSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinase-dependent cellular responses.?Highlighting its potential as a novel cancer therapy, the inhibitor was also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures.
Chemical Properties
Molecular Weight397.38
FormulaC20H17F2N5O2
Cas No.1622849-43-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 245 mg/mL (616.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5165 mL12.5824 mL25.1648 mL125.8241 mL
5 mM0.5033 mL2.5165 mL5.0330 mL25.1648 mL
10 mM0.2516 mL1.2582 mL2.5165 mL12.5824 mL
20 mM0.1258 mL0.6291 mL1.2582 mL6.2912 mL
50 mM0.0503 mL0.2516 mL0.5033 mL2.5165 mL
100 mM0.0252 mL0.1258 mL0.2516 mL1.2582 mL

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