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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12721 | Rho-Kinase-IN-1 | ROCK | |
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... | |||
T2633 | GSK429286A | RHO-15 | ROCK |
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM). | |||
T80175 | Conopeptide rho-TIA | Adrenergic Receptor | |
Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitive inhibitor at the α1A and α1D-Adrenergic Receptors. Binding t... | |||
T61497 | Rho-Kinase-IN-2 | ||
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5... | |||
T2155 | Thiazovivin | ROCK | |
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC. | |||
TQ0187 | SR-3677 | ROCK , Autophagy | |
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). | |||
T12747 | ROCK2-IN-2 | ROCK | |
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM). | |||
T1870 | Y-27632 | ROCK , Apoptosis | |
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. | |||
T14960 | Chroman 1 | ROCK | |
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM). | |||
T7391 | SAR407899 | ROCK , Rho | |
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. | |||
T15798 | LX7101 | ROCK , LIM Kinase , PKA | |
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM). | |||
T12746 | ROCK inhibitor-2 | ROCK | |
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively). | |||
TQ0183 | Narciclasine | Lycoricidinol | ROCK |
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity. | |||
T7301 | BDP5290 | ROCK | |
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.) | |||
T3513 | GSK180736A | GSK180736 | ROCK , GRK , PKA |
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM). | |||
T1898 | RKI-1447 | RKI1447 | ROCK |
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. | |||
T7764 | CCG-222740 | ROCK , Rho , Ras | |
CCG-222740 is an inhibitor of Rho/MRTF pathway | |||
T4095 | ZINC00881524 | ROCK inhibitor | ROCK |
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor. | |||
T2011 | RKI1313 | RKI 1313,RKI-1313 | ROCK |
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion. | |||
T14989 | CMPD101 | ROCK , GRK , PKC | |
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I... |