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GSK180736A

Catalog No. T3513    CAS 817194-38-0    Synonyms: GSK180736

GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).

Pack Size Availability Price/USD Quantity
2 mg In stock 60.00
5 mg In stock 75.00
10 mg In stock 101.00
25 mg In stock 200.00
50 mg In stock 360.00
100 mg In stock 665.00
1 mL * 10 mM (in DMSO) In stock 75.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).

Receptor:

GRK1; GRK2; GRK5; PKA; ROCK;

Chemical Information:
Molecular Weight 365.13
Formula C19H16FN5O2
CAS Number 817194-38-0
Solubility

DMSO: 68 mg/mL (186.2 mM)

Ethanol: 3 mg/mL (8.21 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.