plk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40265	PLK1-IN-2	PLK1-IN-2
	PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.
T2704	MLN0905	PLK1 Inhibitor	PLK
	MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).		PLK
T71718	Plk1 PBD-IN-143
	Plk1 PBD-IN-143 is a novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD).
T63886	PLK1-IN-4
	PLK1-IN-4 is a potent and selective inhibitor of PLK1 (IC50<0.508 nM). PLK1-IN-4 exhibits broad anti-proliferative effects on a wide range of cancer cells. PLK1-IN-4 is able to block the cell cycle in G2/M phase and indu...
T74777	PLK1-IN-6
	PLK1-IN-6, a potent and selective inhibitor of PLK1, demonstrates significant anti-proliferative activities against cancer cells with an IC50 value of 0.45 nM [1].
T81440	PLK1-IN-7
	PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].
T64058	PLK1/BRD4-IN-1
	PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM). It has been shown to have good anti-tumour effects in vivo.
T81441	PLK1/p38γ-IN-1		p38 MAPK
	PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular carcinoma and hepatoblastoma cell lines in vitro [1].		p38 MAPK
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...		PLK
T6282	GSK461364	GSK461364A	PLK
	GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.		PLK
T22700	Cyclapolin 9		PLK
	Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.		PLK
T2634	Ro3280	RO 3280,Ro5203280	PLK
	Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).		PLK
TN3848	Dihydrobaicalein		PLK
	Dihydrobaicalein is a natural product from Scutellaria baicalensis, a PLK1 inhibitor (IC50:6.3 μM).Dihydrobaicalein inhibits VRK2 and PLK2.		PLK
T2271	SBE13 Hydrochloride	SBE 13 hydrochloride,SBE 13 HCl	Apoptosis , PLK , Autophagy
	SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.		Apoptosis , PLK , Autophagy
T6247	Onvansertib	NMS-P937,NMS-1286937	Apoptosis , PLK
	Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.		Apoptosis , PLK
T2438	HMN-214	IVX-214,HMN214	PLK
	HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.		PLK
T15454	GW843682X	GW843682	VEGFR , PLK , CDK , PDGFR , Aurora Kinase
	GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).		VEGFR , PLK , CDK , PDGFR , Aurora Kinase
T17008	TC-S 7005		PLK
	TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).		PLK
T6173	BI 2536		Apoptosis , Epigenetic Reader Domain , PLK
	BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.		Apoptosis , Epigenetic Reader Domain , PLK
T28904	T521	T 521	PLK
	T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.		PLK