20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T35827L | PKCε Inhibitor Peptide acetate | PKCε Inhibitor Peptide acetate(182683-50-7 Free base) | PKC |
PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-,... | |||
T35827 | Epsilon-V1-2 | PKCε Inhibitor Peptide,Protein Kinase Cɛ Inhibitor Peptide,ɛV1-2 | |
Protein kinase C (PKC ) is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase involved in diverse signaling pathways, including those involved in neuronal signaling, cytoskeletal f... | |||
T80248 | PKCε (85-92) | PKC | |
PKCε (85-92) is a biologically active peptide that functions as a specific activator of ε-PKC and induces MARCKS phosphorylation in wild-type cells, but does not affect MARCKS phosphorylation in cells derived from knocko... | |||
T80511 | PKCε inhibitor peptide,myristoylated | Myr‐PKCɛ- | PKC |
Myristoylated PKCε inhibitor peptide (Myr-PKCε-) is a cell-permeable inhibitor consisting of a peptide linked to myristic acid that specifically inhibits protein kinase C epsilon (PKCε), consequently diminishing nitric o... | |||
T81450 | PKCε Inhibitor Scramble Peptide | ||
PKCε Inhibitor Scramble Peptide consists of the same amino acid sequence as the PKCε inhibitor peptide, but in a randomized order. | |||
TP1051 | Protein Kinase C Peptide Substrate | PRKCE,Peptide Epsilon,PKCε | |
Protein Kinase C Peptide Substrate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-coupled recept... | |||
T12494 | PKC-IN-1 | PKC | |
PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively). | |||
T10980 | DCPLA-ME | Methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoate,2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester,Methyl 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoate,DCPLA methyl ester | PKC |
DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator. | |||
T16791 | Rottlerin | Mallotoxin,NSC 56346,NSC 94525 | CaMK , Apoptosis , Others , HIV Protease , PKA , PKC , Autophagy |
Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase... | |||
T4391 | Syk Inhibitor II dihydrochloride | Syk Inhibitor II (hydrochloride) | Others , Tyrosine Kinases , Syk , PKC , BTK |
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun... | |||
T6278 | Sotrastaurin | AEB071 | PKC |
Sotrastaurin (AEB071) is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ). | |||
T6280 | Enzastaurin | LY317615 | Apoptosis , PKC , Autophagy |
Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε. | |||
T6643 | Ro 31-8220 Mesylate | Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate | PKC |
Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β. | |||
T13637 | DCP-LA | FR236924 | PKC |
DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε. | |||
T6643L | Ro 31-8220 | ||
Ro 31-8220 is a potent inhibitor of PKC with IC 50 s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and G... | |||
T6680 | Staurosporine | Antibiotic AM-2282,AM-2282,CGP 41251 | Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal |
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces... | |||
T82007 | JH-131e-153 | ||
JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈R592A≈W588A. This compound’s C1 domain shares homology in seq... | |||
TN1047 | Ingenol mebutate | Ingenol 3-Angelate,PEP005 | gp120/CD4 , HIV Protease , PKC |
Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory a... | |||
T10549 | Bisindolylmaleimide VIII acetate | Ro 31-7549 acetate,Bis VIII acetate | Apoptosis , PKC |
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, resp... | |||
T78833 | AJH-836 | PKC | |
AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation of Munc13-1 from the cytoplasm to the plasma membrane. It is uti... |