Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
2 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 209.00 | |
10 mg | In stock | $ 349.00 | |
25 mg | In stock | $ 577.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 196.00 |
Description | Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity. |
Targets&IC50 | PKCδ:0.376 nM (Ki), PKCα:0.3 nM (Ki), PKCγ:0.162 nM (Ki), PKCε:0.171 nM (Ki), PKCβ:0.105 nM (Ki) |
In vitro | Ingenol mebutate shows EC50s for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-δ, PKC-ε and PKC-μ of 13, 4.37, 10.5, 38.6, 1.08 and 0.9 nM in WEHI-231 cells. The EC50s are 198, 69.1, 4.6, 1 nM in HOP-92 cells for PKC-α, PKC-βI, PKC-ε, PKC-μ and 635, 146, 4.7, 1.1, 30 nM for PKC-α, PKC-βI, PKC-δ, PKC-ε, PKC-μ in Colo-205 cells. Ingenol mebutate sensitizes WEHI-231 cells, HOP-92 and Colo-205 cells with IC50s of 1.41, 3.24, and 11.9 nM, respectively[2]. Ingenol mebutate (20 nM) induces apoptosis in a PKC-δ dependent manner in primary AML marrow blasts but not in normal myeloblasts[3]. |
Source |
Synonyms | Ingenol 3-Angelate, PEP005 |
Molecular Weight | 430.53 |
Formula | C25H34O6 |
CAS No. | 75567-37-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (209 mM)
You can also refer to dose conversion for different animals. More
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Ingenol mebutate 75567-37-2 Chromatin/Epigenetic Cytoskeletal Signaling Immunology/Inflammation Microbiology/Virology Proteases/Proteasome PKC HIV Protease gp120/CD4 Ingenol 3-Angelate PEP 005 PEP005 PEP-005 inhibitor inhibit