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Rottlerin

Catalog No. T16791 CAS 82-08-6

Synonyms: Mallotoxin, NSC 56346, NSC 94525

Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.

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Rottlerin, CAS 82-08-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 118.00

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Purity: 97.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
Targets&IC50	PKCα:30 μM(baculovirus-infected Sf9 insect cells), PKCη:82 μM(baculovirus-infected Sf9 insect cells), PKCδ:3 μM(Porcine spleen), PKCγ:40 μM(baculovirus-infected Sf9 insect cells), PKA:78 μM, PKCζ:100 μM(baculovirus-infected Sf9 insect cells), PKCε:100 μM(baculovirus-infected Sf9 insect cells), CK2:30 μM(holoenzyme expressed in E.coli), PKCβ:42 μM(baculovirus-infected Sf9 insect cells)
In vitro	Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2].
In vivo	Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3].

Synonyms	Mallotoxin, NSC 56346, NSC 94525
Molecular Weight	516.54
Formula	C30H28O8
CAS No.	82-08-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (3.87 mM), Sonication is recommended.

References and Literature

1. Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8. 2. Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77(6):460-70. 3. Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.

Citations

1. Qin X, Liu B, Gao F, et al. Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling. Frontiers in Physiology. 2022: 455.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library TGF-beta/Smad Compound Library Inhibitor Library Kinase Inhibitor Library Flavonoid Natural Product Library Bioactive Compounds Library Max Anti-Obesity Compound Library Anti-Tumor Natural Product Library Cytoskeletal Signaling Pathway Compound Library Neuronal Signaling Compound Library

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Keywords

Rottlerin 82-08-6 Apoptosis Tyrosine Kinase/Adaptors Proteases/Proteasome Autophagy Chromatin/Epigenetic Cytoskeletal Signaling Others Neuroscience Microbiology/Virology PKA PKC HIV Protease CaMK Mallotoxin inhibit NSC94525 Inhibitor Human immunodeficiency virus Protein kinase C NSC-94525 NSC 56346 HIV NSC-56346 NSC56346 NSC 94525 inhibitor

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