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Cytoskeletal Signaling PKC Rottlerin

Rottlerin

Catalog No. T16791   CAS 82-08-6
Synonyms: Mallotoxin, NSC 56346, NSC 94525

Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.

Rottlerin, CAS 82-08-6
Pack Size Availability Price/USD Quantity
2 mg In stock 69.00
5 mg In stock 96.00
10 mg In stock 135.00
25 mg In stock 290.00
50 mg In stock 435.00
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Purity 97.41%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
Targets&IC50 PKCδ ,   PKCα ,   PKCγ ,   PKCβ ,   PKCη ,   PKCζ ,   PKCε ,   CKII ,   PKA ,   CaM kinase III
In vivo Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3].
Synonyms Mallotoxin , NSC 56346 , NSC 94525
Purity 97.41%
Molecular Weight 516.54
Formula C30H28O8
CAS No. 82-08-6

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 2 mg/mL (3.87 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8. 2. Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77(6):460-70. 3. Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Anti-infection Compound Library Apoptosis Compound Library Autophagy Compound Library Selected Plant-sourced Compound Library Kinase Inhibitor Library GPCR Compound Library Antitumor Natural Products Library Covalent Inhibitor Library

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