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Search Results for " pif "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16670	PS210		PDK
	PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1, without acting against other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves ...		PDK
T77749	Upifitamab		Others
	Upifitamab is a naked antibody to upifitamab rilsodotin, which can be used to synthesize the antibody-coupled active molecule UPRI, which can be used to study cancer.		Others
T6271	Tipifarnib	R115777,Zarnestra,IND 58359	Transferase
	Tipifarnib (IND 58359) is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnes...		Transferase
T12472	Pifithrin-α, p-Nitro, Cyclic	PFN-α	p53
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.		p53
T2707	Pifithrin-α hydrobromide	Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide	Ferroptosis , Aryl Hydrocarbon Receptor , p53
	Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.		Ferroptosis , Aryl Hydrocarbon Receptor , p53
T17102	Tipifarnib (S enantiomer)	Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer	Transferase
	Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).		Transferase
T6210	Pifithrin-μ	PFTμ,NSC 303580,2-Phenylethynesulfonamide	HSP , p53 , Autophagy
	Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.		HSP , p53 , Autophagy
T3637	Pifithrin-β hydrobromide	Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis , p53
	Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder...		Ferroptosis , p53
T31224	Piflufolastat	DCFPYL	Epigenetic Reader Domain
	Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA. It is a fluorinated prostate-specific membrane antigen (PSMA) preparation. Piflufolastat can be used to prepare piflufolastat F 18 (DCFPyL F-18).		Epigenetic Reader Domain
T4379	Tropifexor	LJN452	FXR , Autophagy
	Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.		FXR , Autophagy
T21978	P-nitro-Pifithrin-α
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Mor...
T38897	RapiFluor-MS
	RapiFluor-MS labeling used for LC-MS/MS analysis of N-glycans.
T23156	Pifithrin-β		Others
	potent p53 inhibitor		Others
T71882	Pifexole
	Pifexole is the 1,2,4-oxadiazole derivative. It has a similar profile of muscle-relaxant activity in animals to that of chlorzoxazone. In rats, pifexole is reported to be seven times more potent than chlorzoxazone in inh...
T69473	Pifoxime
	Pifoxime, a non-steroidal anti-inflammatory agent (NSAID) and COX-1/2 inhibitor, exhibits anti-inflammatory properties, making it useful in neuropsychiatric research.
T3163	PS 48		PDK
	PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).		PDK
T24676	PS423	PS210AM,PS 210 AM,PS 423,PS210-AM,PS-423
	PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.
T71939	PS77
	PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.
T28458	PS432	PS-432,PS 432
	PS432 is an allosteric inhibitor of atypical PKCs. PS432 targets the PIF-pocket resulting in significantly reduce tumor growth without side effects in mouse xenograft model.
T16671	PS315		PKC
	PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to th...		PKC

Compounds

Synonym: R115777,Zarnestra,IND 58359

Target: Transferase

Pifithrin-α, p-Nitro, Cyclic

T12472

Synonym: PFN-α

Target: p53

Pifithrin-α hydrobromide

T2707

Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide

Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53

Tipifarnib (S enantiomer)

T17102

Synonym: Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer

Target: Transferase

Pifithrin-μ

T6210

Synonym: PFTμ,NSC 303580,2-Phenylethynesulfonamide

Target: HSP, p53, Autophagy

Pifithrin-β hydrobromide

T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Piflufolastat

T31224

Synonym: DCFPYL

Target: Epigenetic Reader Domain

Tropifexor

T4379

Synonym: LJN452

Target: FXR, Autophagy

p-nitro-Pifithrin-α

Synonym: PS210AM,PS 210 AM,PS 423,PS210-AM,PS-423

Synonym: PS-432,PS 432

Cat No.	Product Name	Synonyms	Targets
T3768	Epifriedelanol	Epifriedelinol	Others
	Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary ...		Others
TN4443	Lipiferolide		Telomerase , Antifection
	Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytoto...		Telomerase , Antifection
TN2572	10-O-Caffeoyl-6-epiferetoside		Others
	10-O-Caffeoyl-6-epiferetoside is a natural product for research related to life sciences. The catalog number is TN2572 and the CAS number is 83348-22-5.		Others
TN3968	Epifriedelanol acetate		Others
	Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated d...		Others

Natural Products

Epifriedelanol

T3768

Synonym: Epifriedelinol

Target: Telomerase, Antifection

10-O-Caffeoyl-6-epiferetoside

TN2572

Synonym:

Target: Others

Epifriedelanol acetate

TN3968

Synonym:

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia...
TMPY-03886	MPIF-1/CCL23 Protein, Human, Recombinant	Human	E. coli
	MPIF-1/CCL23 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.4 kDa and the accession number is P55773-1.
TMPK-01201	BPIFA1/LUNX Protein, Human, Recombinant	Human	E. coli
	Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submu...
TMPY-02966	BPIFA2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	BPIFA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.8 kDa and the accession number is Q96DR5.
TMPY-03121	BPIFA2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BPIFA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q96DR5.
TMPY-03851	BPIFB1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BPIFB1, also known as LPLUNC1, belongs to the BPI/LBP/Plunc superfamily, plunc family. BPIFB1 may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. BPIFB1 is express...
TMPY-00168	MPIF-1/CCL23 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	MPIF-1/CCL23 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.9 kDa and the accession number is P55773.3.