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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36315 | NVS-PI3-4 | NVS-PI3-4 | |
NVS-PI3-4 is a highly selective inhibitor of the enzyme PI3Kγ. It is specifically designed for use in scientific investigations related to allergies, inflammatory conditions, and cancerous diseases[1][2]. | |||
T35526 | PI3-Kinase α Inhibitor 2 (hydrochloride) | PI3-Kinase α Inhibitor 2 (hydrochloride) | |
PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor. | |||
T35525 | PI3-Kinase α Inhibitor 2 | PI3-Kinase α Inhibitor 2 | |
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed ... | |||
T1667 | Tandutinib | MLN518,CT53518,NSC726292 | Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit |
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu... | |||
T64392 | PI3K-IN-46 | PI3K | |
PI3K-IN-46 is a specific inhibitor of PI3Kγ. | |||
T12459 | PI3K/mTOR Inhibitor-2 | PI3K , mTOR | |
PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity. | |||
T61618 | PI3K-IN-38 | PI3K | |
PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activity and inhibits tumor growth in vivo. | |||
T60564 | PI3K/Akt/mTOR-IN-2 | Apoptosis , Akt , PI3K , mTOR | |
PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces c... | |||
T77667 | PI3Kδ-IN-16 | Apoptosis , PI3K | |
PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis. | |||
T12589 | PI3Kα/mTOR-IN-1 | PI3K , mTOR | |
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively. | |||
T5831 | Selective PI3Kδ Inhibitor 1 | PI3K | |
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM). | |||
T12462 | PI3Kδ-IN-1 | PI3K | |
PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM). | |||
T60196 | IHMT-PI3Kδ-372 S-isomer | PI3K | |
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ... | |||
T26252 | PI3Kδ-IN-3 | TC KHNS 11 | PI3K |
PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function. | |||
T35530 | IHMT-PI3Kδ-372 | IHMT-PI3Kδ-372 | PI3K |
IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease. | |||
T1826 | PI3K-IN-1 | Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 | DNA-PK , PI3K |
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. | |||
T12365 | PARP/PI3K-IN-1 | PARP , PI3K | |
PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ... | |||
T10804 | CHMFL-PI3KD-317 | PI3K , PI4K | |
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, ... | |||
T62103 | COX-2/PI3K-IN-1 | ||
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM). | |||
T62289 | PI3KC2α-IN-1 | ||
PI3KC2α-IN-1 is a potent inhibitor of PI3KC2α with an IC50 value of 95 nM. PI3KC2α-IN-1 interacts with the ATP binding site of PI3KC2α. PI3KC2α-IN-1 impairs the kinetics of endocytosis and membrane remodelling. PI3KC2α-I... |