pgd2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4624	PGD2-IN-1	PGD2-inhibitor	Prostaglandin Receptor
	PGD2-IN-1 (PGD2-inhibitor) is an effective DP receptor antagonist (IC50:0.3 nM), a compound that can inhibit prostaglandin D2 (PGD2) signaling. PGD2-IN-1 specifically targets and regulates the activity of PGD2 receptors ...		Prostaglandin Receptor
T13831	Prostaglandin D2	PGD2	Endogenous Metabolite
	Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals,and is a potent endogenous sleep promoting substances.		Endogenous Metabolite
T17232	Vidupiprant	AMG 853	Prostaglandin Receptor
	Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.		Prostaglandin Receptor
T1804	HPGDS inhibitor 1	HPGDS-inhibitor-1	PGE Synthase
	HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.		PGE Synthase
T37264	15(R)-15-methyl Prostaglandin D2	15(R)15methyl PGD2	GPR
	15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis.		GPR
T16280	Nedocromil	FPL 59002	Leukotriene Receptor , Prostaglandin Receptor , Histamine Receptor
	Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T3520	Setipiprant	KYTH-105,ACT-129968	GPR , Prostaglandin Receptor
	Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...		GPR , Prostaglandin Receptor
T15712	Laropiprant	MK-0524	Prostaglandin Receptor
	Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).		Prostaglandin Receptor
T7652	AM211	AM211 free acid	Prostaglandin Receptor
	AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)		Prostaglandin Receptor
T14565	BI-671800	AP-761,Cmpd A	GPR , Prostaglandin Receptor
	BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...		GPR , Prostaglandin Receptor
T2690	Tranilast	MK 341,SB 252218	RAAS , Prostaglandin Receptor
	Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.		RAAS , Prostaglandin Receptor
T1866	AT-56		Others , PGE Synthase
	AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.		Others , PGE Synthase
T2396	Ramatroban	BAY u3405	GPR , Prostaglandin Receptor , PPAR
	Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.		GPR , Prostaglandin Receptor , PPAR
T2664	Timapiprant	OC000459	GPR , Prostaglandin Receptor
	Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).		GPR , Prostaglandin Receptor
T7359	CAY10471 Racemate	TM30089 Racemate	GPR , Prostaglandin Receptor
	CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel...		GPR , Prostaglandin Receptor
T36153	15(S)-15-methyl Prostaglandin D2	15(S)-15-methyl Prostaglandin D2
	15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with m...
T36213	16,16-dimethyl Prostaglandin D2	16,16-dimethyl Prostaglandin D2
	16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. It enhances ADP-induced human platelet aggregation and increases systemic blood pressure in rats.
T36545	Prostaglandin D2 methyl ester	Prostaglandin D2 methyl ester
	Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten...
T38257	PGDM
	Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smoot...
T69967	Laropiprant analog
	Laropiprant analog is an antagonist of the prostaglandin PGD2 receptor DP1.