Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 249.00 | |
50 mg | In stock | $ 482.00 | |
100 mg | In stock | $ 689.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2) |
Targets&IC50 | Rat DP2:10.4 nM, Mouse DP2:7.8 nM , Guinea pig DP2:4.9 nM , Human DP2:4.9 nM |
In vivo | AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay. AM211 demonstrates efficacy in two animal models of allergic inflammation, including an ovalbumin-induced lung inflammation model in guinea pigs and an ovalbumin-induced mouse model of allergic rhinitis. AM211 represents a potent and selective antagonist of DP2 that may be used clinically to evaluate the role of DP2 in T helper 2-driven allergic inflammatory diseases[1]. |
Synonyms | AM211 free acid |
Molecular Weight | 500.51 |
Formula | C27H27F3N2O4 |
CAS No. | 1175526-27-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (249.75 mM)
You can also refer to dose conversion for different animals. More
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AM211 1175526-27-8 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor inhibit AM-211 Inhibitor AM211 free acid AM 211 inhibitor