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AM211

Catalog No. T7652   CAS 1175526-27-8
Synonyms: AM211 free acid

AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)

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AM211 Chemical Structure
AM211, CAS 1175526-27-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 122.00
25 mg In stock $ 249.00
50 mg In stock $ 482.00
100 mg In stock $ 689.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
Targets&IC50 Rat DP2:10.4 nM, Mouse DP2:7.8 nM , Guinea pig DP2:4.9 nM , Human DP2:4.9 nM
In vivo AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay. AM211 demonstrates efficacy in two animal models of allergic inflammation, including an ovalbumin-induced lung inflammation model in guinea pigs and an ovalbumin-induced mouse model of allergic rhinitis. AM211 represents a potent and selective antagonist of DP2 that may be used clinically to evaluate the role of DP2 in T helper 2-driven allergic inflammatory diseases[1].
Synonyms AM211 free acid
Molecular Weight 500.51
Formula C27H27F3N2O4
CAS No. 1175526-27-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (249.75 mM)

TargetMolReferences and Literature

1. Bain G , Lorrain D S , Stebbins K J , et al. Pharmacology of AM211, a Potent and Selective Prostaglandin D2 Receptor Type 2 Antagonist That Is Active in Animal Models of Allergic Inflammation[J]. Journal of Pharmacology and Experimental Therapeutics, 2011, 338(1):290-301. 2. Bain G , King C D , Brittain J , et al. Pharmacodynamics, Pharmacokinetics, and Safety of AM211: A Novel and Potent Antagonist of the Prostaglandin D2 Receptor Type 2[J]. The Journal of Clinical Pharmacology, 2012, 52(10).

Related compound libraries

This product is contained In the following compound libraries:
ReFRAME Related Library NO PAINS Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Bioactive Compounds Library Max Orally Active Compound Library GPCR Compound Library Inhibitor Library Anti-Aging Compound Library

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Keywords

AM211 1175526-27-8 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor inhibit AM-211 Inhibitor AM211 free acid AM 211 inhibitor

 

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