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AM211

Name: AM211
Brand: TargetMol
SKU: T7652
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7652Cas No. 1175526-27-8

Alias AM211 free acid

AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)

AM211

🥰Excellent

Catalog No. T7652Alias AM211 free acidCas No. 1175526-27-8

AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$247	In Stock
50 mg	$378	In Stock
100 mg	$559	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Batch Information

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Purity:≥95%

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COA HNMR

Product Introduction

Bioactivity

Description	AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
Targets&IC50	DP2 (mouse):7.8 nM , DP2 (rat):10.4 nM, DP2 (guinea pig):4.9 nM , DP2 (human):4.9 nM
In vivo	AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay. AM211 demonstrates efficacy in two animal models of allergic inflammation, including an ovalbumin-induced lung inflammation model in guinea pigs and an ovalbumin-induced mouse model of allergic rhinitis. AM211 represents a potent and selective antagonist of DP2 that may be used clinically to evaluate the role of DP2 in T helper 2-driven allergic inflammatory diseases[1].
Synonyms	AM211 free acid

Chemical Properties

Molecular Weight	500.51
Formula	C₂₇H₂₇F₃N₂O₄
Cas No.	1175526-27-8
Smiles	CCN(Cc1cc(ccc1-c1cc(CC(O)=O)ccc1OC)C(F)(F)F)C(=O)NCc1ccccc1
Relative Density.	1.264 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (249.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9980 mL	9.9898 mL	19.9796 mL	99.8981 mL
5 mM	0.3996 mL	1.9980 mL	3.9959 mL	19.9796 mL
10 mM	0.1998 mL	0.9990 mL	1.9980 mL	9.9898 mL
20 mM	0.0999 mL	0.4995 mL	0.9990 mL	4.9949 mL
50 mM	0.0400 mL	0.1998 mL	0.3996 mL	1.9980 mL
100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc