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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12364 | PARP-2-IN-1 | Others | |
PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM). | |||
T62281 | PARP-1-IN-2 | PARP | |
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel... | |||
T72862 | PARP-2/1-IN-2 | ||
PARP-2/1-IN-2, an enantiomer of Veliparib, serves as a potent inhibitor of PARP, demonstrating inhibition constants (Kis) of 2 nM for PARP-2 and 5 nM for PARP-1. This compound exhibits a half-maximal effective concentrat... | |||
T9891 | PARP1-IN-8 | N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide | PARP |
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM). | |||
T40310 | PARP/EZH2-IN-1 | PARP/EZH2-IN-1 | |
PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type B... | |||
T62508 | PARP-1/2-IN-1 | ||
PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM). | |||
T78787 | PARP-1/2-IN-2 | PARP | |
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound... | |||
T78157 | PARP-1-IN-3 | Apoptosis , PARP | |
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell... | |||
T72437 | PARP1/2/TNKS1/2-IN-1 | Apoptosis , PARP , Wnt/beta-catenin | |
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis. | |||
T6768 | AZ6102 | PARP , Wnt/beta-catenin | |
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. | |||
T22264 | AZ9482 | PARP | |
AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells. | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T3S1471 | Cucurbitacin IIA | Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA | Apoptosis , Survivin |
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ... | |||
T2S2362 | Dehydrocorydaline nitrate | BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy | |
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... | |||
T5S1805 | 5,7-Dihydroxychromone | 5,7-Dihydroxy-4H-Chromen-4-One | Others , Virus Protease , PARP , Caspase , Nrf2 |
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai... | |||
T81543 | PARP1-IN-17 | PARP | |
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis. It exhibits robust anti-proliferative activity [1]. | |||
T61335 | Rucaparib hydrochloride | ||
Rucaparib hydrochloride, also known as AG014699, is a powerful and orally active compound that inhibits PARP proteins including PARP-1, PARP-2, and PARP-3 with a Ki value of 1.4 nM for PARP1. Additionally, Rucaparib hydr... | |||
T63065 | Rucaparib tartrate | ||
Rucaparib (AG014699) tartrate is an orally active inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) and acts on PARP-1 (Ki: 1.4 nM).Rucaparib tartrate is a hexose hexaphosphate dehydrogenase (H6PD) inhibitor. Rucapa... | |||
T61657 | Rucaparib acetate | ||
Rucaparib (AG014699) acetate is a highly effective oral inhibitor of PARP proteins, specifically targeting PARP-1, PARP-2, and PARP-3, with a Ki value of 1.4 nM for PARP1. Additionally, it exhibits inhibitory action on h... | |||
T71026 | MC2050 HCl | ||
MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide trea... |