parp — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12365	PARP/PI3K-IN-1		PARP , PI3K
	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ...		PARP , PI3K
T78182	PARP-1-IN-4		Others , PARP
	PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.		Others , PARP
T62281	PARP-1-IN-2		PARP
	PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel...		PARP
T78157	PARP-1-IN-3		Apoptosis , PARP
	PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell...		Apoptosis , PARP
T40310	PARP/EZH2-IN-1	PARP/EZH2-IN-1
	PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type B...
T73027	PARP-2-IN-3		Apoptosis , PARP
	PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for the study of breast cancer.CAS 번호128-52-56-8		Apoptosis , PARP
T6329	3-Aminobenzamide	3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001	PARP
	3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.		PARP
T12364	PARP-2-IN-1		Others
	PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).		Others
T72862	PARP-2/1-IN-2
	PARP-2/1-IN-2, an enantiomer of Veliparib, serves as a potent inhibitor of PARP, demonstrating inhibition constants (Kis) of 2 nM for PARP-2 and 5 nM for PARP-1. This compound exhibits a half-maximal effective concentrat...
T79330	PARP-1-IN-13		PARP
	PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondri...		PARP
T61798	PARP-1-IN-1
	PARP-1-IN-1 is a highly selective and orally active inhibitor of the enzyme PARP-1, with an IC50 value of 0.96 nM. It exhibits excellent tolerance and demonstrates significant activity in a single dose in the MDA-MB-436 ...
T79647	VEGFR/PARP-IN-1		PARP
	VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. Thi...		PARP
T62508	PARP-1/2-IN-1
	PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM).
T61962	PARP-1/HDAC-IN-1
	PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities.
T74173	PROTAC PARP/EGFR ligand 1
	PROTAC PARP/EGFR ligand 1 is a potent compound utilized in the creation of dual PARP-EGFR degraders through Proteolytic Targeting Chimera (PROTAC) technology [1].
T78787	PARP-1/2-IN-2		PARP
	PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound...		PARP
T9610	PARP1-IN-5 dihydrochloride		PARP
	PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.		PARP
T6842	G007-LK		PARP , Wnt/beta-catenin
	G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.		PARP , Wnt/beta-catenin
T15639	K-756		PARP , Wnt/beta-catenin
	K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectively).		PARP , Wnt/beta-catenin
T8964	G244-LM		Others , PARP
	G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.		Others , PARP