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3-Aminobenzamide

Catalog No. T6329 CAS 3544-24-9

Synonyms: 3-AB, INO1001, INO-1001, 3-ABA, PARP-IN-1, INO 1001

3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.

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3-Aminobenzamide, CAS 3544-24-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 37.00
200 mg	In stock	$ 48.00
500 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.84%

Purity: 99.5%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
Targets&IC50	PARP:<50 nM
In vitro	INO-1001 (>1 μM) leads to more than 95% inhibition of PARP activity without significant cellular toxicity. In addition, INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. [1] Inhibition of PARP activity by INO-1001 significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM Water2. [2]
In vivo	In a db/db (Leprdb/db) mouse model, INO-1001 ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. [3] Treatment with INO-1001 (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice. [4]
Kinase Assay	PARP activity is measured with a PARP Activity Assay Kit. This method measures relative PARP activity by determining the level of incorporation of?3H-NAD into trichloroacetic acid (TCA) precipitable material in the presence of sheared genomic DNA, which activates PARP. The reaction mixture is added directly to washed cultures in 12-well culture plates and the reaction is allowed to proceed for 60 minutes at 37°C before the cells are removed mechanically, transferred to a microcentrifuge tube, and precipitated with ice-cold 5% TCA.

Synonyms	3-AB, INO1001, INO-1001, 3-ABA, PARP-IN-1, INO 1001
Molecular Weight	136.15
Formula	C7H8N2O
CAS No.	3544-24-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 26 mg/mL (191 mM)

DMSO: 26 mg/mL (191 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Brock WA, et al. Cancer Lett. 2004, 205(2), 155-160. 2. Radovits T, et al. Eur J Pharmacol. 2007, 564(1-3), 158-166. 3. Szabó C, et al. Diabetes. 2006, 55(11), 32004-32012. 4. Clark RS, et al. J Neurotrauma. 2007, 24(8), 1399-1405. 5. Toshimitsu H, et al. Ann Surg Oncol. 2010, 17(8), 2247-2254.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Epigenetics Compound Library DNA Damage & Repair Compound Library

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Tankyrase-IN-5 3-Methoxybenzamide Rucaparib IVHD-valtrate PARP7-IN-16 EB-47 Mefuparib hydrochloride Simmiparib

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Keywords

3-Aminobenzamide 3544-24-9 Chromatin/Epigenetic DNA Damage/DNA Repair PARP 3-AB inhibit INO1001 3Aminobenzamide poly ADP ribose polymerase Inhibitor INO-1001 3-ABA PARP-IN-1 INO 1001 3 Aminobenzamide inhibitor

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