Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 313.00 | |
25 mg | In stock | $ 622.00 | |
50 mg | In stock | $ 872.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 259.00 |
Description | PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. |
Targets&IC50 | PARP1:14.7 nM, PARP2:0.9 μM |
In vitro | PARP1-IN-5 dihydrochloride (0.1~10 μM) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 dihydrochloride (0.1~10 μM) decreases the expressions of MCM2-7 on SK-OV-3 cells. PARP1-IN-5 dihydrochloride (0.1~320 μM) has little cytotoxic effects on A549 cells. PARP1-IN-5 dihydrochloride can significantly decrease the PAR level on SK-OV-3 cells[1]. PARP1-IN-5 dihydrochloride exerts antitumor effects through PARP-1. PARP1-IN-5 dihydrochloride could increase the γ-H2AX expression[1]. |
In vivo | PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine[1]. PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg[1]. PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1[1]. PARP1-IN-5 dihydrochloride can decrease the expression of PAR and upregulate the expression of γ-H2AX [1]. |
Molecular Weight | 537.46 |
Formula | C25H26Cl2N2O5S |
CAS No. | 2823308-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (232.58 mM), Sonication is recommended.
H2O: 1 mg/mL (1.86 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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PARP1-IN-5 dihydrochloride 2823308-89-8 Chromatin/Epigenetic DNA Damage/DNA Repair PARP PARP1 IN 5 dihydrochloride PARP1-IN-5 Dihydrochloride PARP-1-IN-5 (dihydrochloride) PARP1IN5 dihydrochloride PARP1-IN-5 inhibitor inhibit