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G244-LM

Catalog No. T8964 CAS 1563007-08-8

G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.

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G244-LM, CAS 1563007-08-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00

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Purity: 98.46%

Biological Description

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Description

G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.

In vitro

G244-LM is a potent and specific small-molecule tankyrase inhibitors, that reduce Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization.?The novel tankyrase inhibitors completely block ligand-driven Wnt/β-catenin signaling in cell culture and display approximately 50% inhibition of APC mutation-driven signaling in most CRC cell lines.?It was previously unknown whether the level of AXIN protein stabilization by tankyrase inhibition is sufficient to impact tumor growth in the absence of normal APC activity.

Molecular Weight	406.52
Formula	C18H22N4O3S2
CAS No.	1563007-08-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mM

References and Literature

1. Lau T , Chan E , Callow M , et al. A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth[J]. Cancer Research, 2013, 73(10):3132-3144.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Epigenetics Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

G244-LM 1563007-08-8 Chromatin/Epigenetic DNA Damage/DNA Repair Others PARP Inhibitor G244LM inhibit poly ADP ribose polymerase G244 LM G-244-LM inhibitor

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