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Search Results for " mds "

10

Compounds

Cat No. Product Name Synonyms Targets
T4570 Pipobroman Vercyte,A-8103,Amedel Others , DNA Alkylator/Crosslinker
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...
T5097 Ezatiostat TER199(free base),TLK199 Apoptosis , Glutathione Peroxidase , GST
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
TQ0059 Ilorasertib ABT-348 VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...
T22776 Ezatiostat hydrochloride TLK199 HCl,TER199 Glutathione Peroxidase
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydr...
T76975 Tomaralimab OPN-305 TLR
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).
T6332 Pevonedistat MLN4924 E1/E2/E3 Enzyme , NEDD8
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity.
T64133L Laniquidar TFA Laniquidar TFA(197509-46-9 Free base),R101933 P-gp
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavailability and can be used to modulate the multidrug resistan...
T16384 Olutasidenib FT-2102 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...
T76911 Asunercept
Asunercept (APG101; CAN008), a soluble CD95-Fc fusion protein, selectively targets and binds to CD95L, effectively disrupting CD95/CD95L signaling. It is utilized in research for treating glioblastoma multiforme (GBM), m...
T64133 Laniquidar
Laniquidar (R101933) is a third generation non-competitive inhibitor of P-glycoprotein (P-gp) (IC50: 0.51 μM) with limited oral bioavailability. It can also be used to modulate multidrug resistance transporters.
TargetMol