keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 65.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 205.00 | |
50 mg | In stock | $ 342.00 | |
100 mg | In stock | $ 583.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 77.00 |
Description | Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity. |
In vivo | Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 2500 mg/day) in combination with 10 mg of lenalidomide on days 1-21 of a 28-day cycle. One of 4 evaluable patients (25%) in the 2500/10 mg dose group experienced an erythroid hematologic improvement (HI-E) response by 2006 MDS International Working Group (IWG) criteria. Four of 10 evaluable patients (40%) in the 2000 mg/10 mg dose group experienced a HI-E response [1]. Systemic inhibition of GSTP1 with Ezatiostat (0-30 mg/kg, i.p.) dose-dependently reduced the reinforcing effects of alcohol as measured by operant self-administration, in the absence of motor effects [2]. |
Synonyms | TER199(free base), TLK199 |
Molecular Weight | 529.65 |
Formula | C27H35N3O6S |
CAS No. | 168682-53-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: >50 mg/mL (94.4 mM)
Ethanol: 20 mg/mL (37.76)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ezatiostat 168682-53-9 Apoptosis Metabolism oxidation-reduction GST Glutathione Peroxidase Inhibitor lymphocyte inhibit Glutathione transferases TLK 199 GSTs Gutathione S-transferase proliferation c-Jun JNK GSTP1 TLK-199 ERK1 MDS TER199(free base) TLK199 tripeptide inhibitor