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Ezatiostat

Ezatiostat
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Purity:97.95%
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Ezatiostat

Catalog No. T5097Cas No. 168682-53-9
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
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Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$65In Stock
10 mg$113In Stock
25 mg$205In Stock
50 mg$342In Stock
100 mg$583In Stock
1 mL x 10 mM (in DMSO)$77In Stock
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Product Introduction

Bioactivity
Description
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
In vivo
Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 2500 mg/day) in combination with 10 mg of lenalidomide on days 1-21 of a 28-day cycle. One of 4 evaluable patients (25%) in the 2500/10 mg dose group experienced an erythroid hematologic improvement (HI-E) response by 2006 MDS International Working Group (IWG) criteria. Four of 10 evaluable patients (40%) in the 2000 mg/10 mg dose group experienced a HI-E response [1]. Systemic inhibition of GSTP1 with Ezatiostat (0-30 mg/kg, i.p.) dose-dependently reduced the reinforcing effects of alcohol as measured by operant self-administration, in the absence of motor effects [2].
AliasTER199(free base), TLK199
Chemical Properties
Molecular Weight529.65
FormulaC27H35N3O6S
Cas No.168682-53-9
Storage & Solubility Information
Storagekeep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: Insoluble
DMSO: >50 mg/mL (94.4 mM)
Ethanol: 20 mg/mL (37.76)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
100 mM0.0189 mL0.0944 mL0.1888 mL0.9440 mL

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