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Ezatiostat hydrochloride

Ezatiostat hydrochloride
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Ezatiostat hydrochloride

Catalog No. T22776Cas No. 286942-97-0
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
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Pack SizePriceAvailabilityQuantity
2 mg$53Backorder
5 mg$75Backorder
10 mg$123Backorder
25 mg$211Backorder
50 mg$323Backorder
100 mg$545Backorder
200 mg$817Backorder
500 mg$1,227Backorder
1 mL x 10 mM (in DMSO)$121Backorder
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Product Introduction

Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
In vitro
Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes [1][2].
In vivo
Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals[2].
AliasTLK199 HCl, TER199
Chemical Properties
Molecular Weight566.11
Cas No.286942-97-0
Storage & Solubility Information
Storagekeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 28.3mg/mL (50.00 mM)
Solution Preparation Table
1 mM1.7664 mL8.8322 mL17.6644 mL88.3221 mL
5 mM0.3533 mL1.7664 mL3.5329 mL17.6644 mL
10 mM0.1766 mL0.8832 mL1.7664 mL8.8322 mL
20 mM0.0883 mL0.4416 mL0.8832 mL4.4161 mL


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