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Ezatiostat hydrochloride

Catalog No. T22776 CAS 286942-97-0

Synonyms: TLK199 HCl, TER199

Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ezatiostat hydrochloride Chemical Structure

Ezatiostat hydrochloride, CAS 286942-97-0

Pack Size	Availability	Price/USD
2 mg	Inquiry	$ 53.00
5 mg	Inquiry	$ 75.00
10 mg	Inquiry	$ 123.00
25 mg	Inquiry	$ 211.00
50 mg	Inquiry	$ 323.00
100 mg	Inquiry	$ 545.00
200 mg	Inquiry	$ 817.00
500 mg	Inquiry	$ 1,227.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 121.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
In vitro	Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes [1][2].
In vivo	Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals[2].

Synonyms	TLK199 HCl, TER199
Molecular Weight	566.11
Formula	C27H36ClN3O6S
CAS No.	286942-97-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28.3mg/mL (50.00 mM)

References and Literature

1. Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298(1):339-45. 2. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20

Related compound libraries

This product is contained In the following compound libraries：

Glutamine Metabolism Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

Tinoridine hydrochloride Glutathione Peroxidase 4-Methylesculetin N-Acetyl lysyltyrosylcysteine amide N-Acetyl lysyltyrosylcysteine amide acetate AZD8309 4-Aminosalicylic acid RSL3

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ezatiostat hydrochloride 286942-97-0 Metabolism Glutathione Peroxidase Glutathione transferases MDS lymphocyte proliferation Ezatiostat GSTs JNK tripeptide TLK199 HCl ERK1 GSTP1 inhibit Gutathione S-transferase TER199 TLK-199 TLK 199 TER 199 Ezatiostat Hydrochloride Apoptosis Inhibitor c-Jun TLK199 TER-199 inhibitor

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