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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T33467 | MOMIPP | PI3K | |
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2]. | |||
T9688 | CC-90001 | JNK | |
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2. | |||
T4646 | TA-02 | p38 MAPK , Autophagy | |
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2. | |||
T6150 | TAK-715 | p38 MAPK , Casein Kinase , JNK | |
TAK-715 is a p38 MAPK inhibitor for p38α. | |||
T3200 | DB07268 | JNK | |
DB07268 is a potent and selective JNK1 inhibitor. | |||
T14895 | Tanzisertib | CC-930 | JNK |
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity. | |||
T3598 | JNK-IN-7 | JNK inhibitor | JNK |
JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase. | |||
T8477 | IQ-3 | JNK | |
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an... | |||
T2668 | JNK-IN-8 | JNK Inhibitor XVI | JNK , c-Kit |
JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ in A375 cell line. | |||
T3109 | SP600125 | 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone | Apoptosis , Ferroptosis , Trk receptor , JNK , Aurora Kinase , Autophagy |
SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis. | |||
T2675 | Bentamapimod | AS 602801 | JNK |
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK. | |||
TN7121 | D-Epigalbacin | (-)-Zuonin A | JNK |
d-Epigalbacin ((-)-Zuonin A) is a naturally occurring lignin. d-Epigalbacin is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively. | |||
T60534 | JNK-IN-11 | ||
JNK-IN-11 (compound 1) is a potent inhibitor of JNK with the potential for Alzheimer's and Parkinson's disease research. JNK-IN-11 has IC50 values of 2.2, 21.4, 1.8 μM for JNK1, JNK2, JNK3, respectively. | |||
T2S2382 | 3'-Hydroxypterostilbene | 3'-HPT | Apoptosis , Autophagy |
3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b... | |||
T6525 | GW 5074 | GW5074,Raf1 Kinase Inhibitor I | Apoptosis , Raf |
GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms. | |||
T6440 | CGP 57380 | MNK1 Inhibitor | Apoptosis , MNK |
CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. | |||
T6S1371 | Isovitexin | Homovitexin,Saponaretin,Apigenin-6-C-Glucoside | NF-κB , JNK , Glucosidase |
1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo. | |||
T3S1641 | Esculentoside H | TNF , NF-κB , JNK | |
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release. | |||
T4S2326 | Cornuside | 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside | ERK , p38 MAPK , NF-κB , JNK |
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi... | |||
T3627 | IQ-1S free acid | IQ-1,IQ-1S,IQ-1S (free acid) | NF-κB , JNK |
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can se... |