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Search Results for " jak2/stat3-in-1 "

9

Compounds

Cat No. Product Name Synonyms Targets
T72754 JAK2/STAT3-IN-1
JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
TJS1779 Protosappanin A PTA NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory ...
T5S0734 Desmethoxyyangonin Desmethoxy yangonin,Demethoxyyangonin,5,6-Dehydrokavain Others , Monoamine Oxidase
1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydr...
T3S1471 Cucurbitacin IIA Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA Apoptosis , Survivin
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...
T62317 α7 nAchR-JAK2-STAT3 agonist 1
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β...
T82229 HD-2a
HA-2a inhibits the JAK2/STAT3 pathway by downregulating circDcbld2 expression in RAW264.7 cells [1].
T79581 JAK2-IN-9 JAK
Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM. It effectively inhibits the phosphorylation of JAK2, STAT3, and STAT5, possesses metabolic stabilities, and induces apoptosis. This com...
T79608 DPP JAK
DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstrating antiproliferative activity. It activates caspase-3 and cleaved poly ADP-ri...
T68306 INCB16562
INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced p...
TargetMol