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Search Result

Search Results for " ire1 "

Targets

IRE1 IRE1

25

Compounds

2

Natural Products

6

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T6363 4μ8C IRE1 Inhibitor III IRE1
4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.
T15594 MKC8866 IRE1
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate ca...
TQ0101 MKC3946 IRE1
MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.
T6681 STF-083010 STF083010 IRE1
STF-083010 is a selective inhibitor of the IRE1α endonuclease.
T12071 MKC9989 IRE1
MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.
T3654 APY29 IRE1
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
TQ0076 KIRA6 IRE1
KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.
T11488 GSK2850163 IRE1
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
T11762L Kira8 AMG-18 IRE1
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).
T9349 IXA4 IRE1
IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.
T9564 IRE1α kinase-IN-1 IRE1
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...
T0374L Sunitinib SU 11248 Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and ga...
T0374 Sunitinib Malate Sutent,SU 11248 (Malate),SU 11248,Sunitinib Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
T79062 IRE1α kinase-IN-8 IRE1
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α. This compound is utilized in research pertaining to diseases linked to the unfolded protein response and regulated I...
T79063 IRE1α kinase-IN-9 IRE1
IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM. It is suitable for research into diseases linked to the unfolded protein response or regulated IRE1...
T63734 IRE1α kinase-IN-5
IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.
T38841 IRE1α kinase-IN-2 IRE1α kinase-IN-2
IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effective...
T40336 IRE1α kinase-IN-6 IRE1α kinase-IN-6
IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.
T63839 IRE1α kinase-IN-3
IRE1α kinase-IN-3 is a potent, ATP-competitive inhibitor of IRE1α (Ki: 480 nM).
T72641 IRE1α kinase-IN-7
IRE1α kinase-IN-7 is a chemical compound functioning as an inhibitor of IRE1α kinase, primarily utilized in the research of diseases related to endoplasmic reticulum stress.
T63511 IRE1α kinase-IN-4
IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].
T62568 IXA6 IRE1
IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's ...
T14847 B I09 Others , IRE1
B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cel...
T64049 KIRA9
KIRA9 is a potent inhibitor of IRE1 with an IC50 value of 4.8 μM for INS-1 cells. KIRA9 completely binds the ATP binding site of IRE1 and blocks endoplasmic reticulum (ER) localised mRNA decay and apoptosis.
T69410 CB5305630
CB5305630 is an IRE1 inhibitor.
Cat No. Product Name Synonyms Targets
T5A2461 Bufotalin Bufotaline Apoptosis , Others , Reactive Oxygen Species
1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.
T17143 Toyocamycin Vengicide Apoptosis , Others , IRE1 , Antibiotic , Antifungal
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.

Natural Products

Bufotalin
T5A2461
Synonym: Bufotaline
Target: Apoptosis, Others, Reactive Oxygen Species
Toyocamycin
T17143
Synonym: Vengicide
Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Recombinant Proteins

Species：
Human (3)
Mouse (3)
Expression System：
Baculovirus-Insect Cells (3)
E. coli (2)
Yeast (1)
Tag：
N-terminal 6xHis-tagged (2)
GST (1)
His,GST (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-04753 IRE1 Protein, Human, Recombinant (aa 465-977) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04413 IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPH-02759 LIRE1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
LIRE1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli.
TMPY-04776 PCTAIRE1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
PCTAIRE1 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells with GST tag. The predicted molecular weight is 82 kDa. Accession number: Q00536-1
TMPH-02638 HSPA5 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its i...
TMPH-02639 HSPA5 Protein, Mouse, Recombinant (His) Mouse Yeast
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its i...
Cat No. Product Name
L9700 Endoplasmic Reticulum Stress Compound Library

193 compounds
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);

Libraries

Endoplasmic Reticulum Stress Compound Library
L9700
Compounds: 193
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