Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 239.00 | |
50 mg | In stock | $ 378.00 | |
100 mg | In stock | $ 568.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM). |
Targets&IC50 | IRE1α RNase activity:200 nM , IRE1α kinase activity:20 nM |
In vitro | The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM). |
Molecular Weight | 446.41 |
Formula | C24H29Cl2N3O |
CAS No. | 2121989-91-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 50 mg/mL (112.00 mM), Sonication is recommended.
DMSO: 67.5 mg/mL (151.21 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK2850163 2121989-91-9 Cell Cycle/Checkpoint IRE1 GSK 2850163 inhibit Inhibitor GSK-2850163 Inositol requiring enzyme 1 inhibitor