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TargetMol | Compound Library

Endoplasmic Reticulum Stress Compound Library

Catalog No. L9700

The endoplasmic reticulum (ER) is the cellular organelle that is critical for protein folding and secretion, calcium homeostasis, and lipid biosynthesis. The ER is the site of multiple post-translational modifications such as glycosylation and disulfide bond formation. It is also the organelle in which proteins are folded into their proper conformation and in which multi-subunit proteins are assembled. Endoplasmic reticulum stress (ER stress), such as unfolded protein response (UPR) and ER overload response (EOR), occurs when proteins are not properly folded or conformed (misfolded protein) or homeostasis cannot be maintained such as disturbances in redox regulation, calcium regulation, glucose deprivation, and viral infection. As a result, ER-localized chaperones such as glucose-regulated proteins (GRP78, GRP94, etc.) are induced, protein synthesis is slowed down, and a protein degrading system is initiated. However, excessive and prolonged stresses lead cells to caspase-12 mediated apoptosis. ER stress occurs not only in both normal and pathophysiological conditions, but has also been implicated in multiple disorders such as cancers, type 2 diabetes, ischemia, viral infection, and neurodegenerative disorders. ER stress can also be induced by hypoxia. This has implications for solid tumors which usually exhibit hypoxia in their cores. Insulin resistance is also associated with ER stress and the treatment of type 2 diabetic mice with chemical chaperones which assist protein folding in the ER restored insulin sensitivity. It has also been proposed that agents that cause ER stress can be used directly as chemotherapeutic agents. TargetMol's Endoplasmic Reticulum Stress Compound Library collects 223 ER stress related compounds, targeting different targets in ER stress signaling pathway such as PERK, IRE1, ATF6, GRP78, etc. It is an effective tool for research in endoplasmic reticulum stress and related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9700

Endoplasmic Reticulum Stress Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 223 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
  • Targets include GRP78, IRE1, ATF6, PERK, etc.
  • Some compounds have been approved by FDA;
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with chemical structure, target, and bioactivity information;
  • NMR and HPLC validated to ensure high purity.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Autophagy
HSP
PERK
IRE1
JNK
Endogenous Metabolite
Sirtuin
AMPK
Mitophagy
Antibacterial
Antibiotic
COX
GPCR
HDAC
NF-κB
Reactive Oxygen Species
Cytochromes P450
ERK
MEK
p97
Phosphatase
Akt
HIV Protease
MMP
PPAR
5-HT Receptor
Calcium Channel
c-Kit
DNA/RNA Synthesis
DUB
Ferroptosis
GABA Receptor
AChR
Antifungal
Antioxidant
Antiviral
ASK
Aurora Kinase
Cannabinoid Receptor
Casein Kinase
Caspase
CDK
Chloride channel
Cholinesterase (ChE)
Dehydrogenase
Dopamine Receptor
Estrogen/progestogen Receptor
FLT
Gamma-secretase
Glutathione Peroxidase
HIF
Histamine Receptor
Lipoxygenase
MAPK
Mdm2
Mitochondrial Metabolism
mTOR
p53
PDGFR
Phospholipase
PI3K
Prostaglandin Receptor
Proteasome
SARS-CoV
Sodium Channel
Src
TGF-beta/Smad
VEGFR
Adenosine Deaminase
Adrenergic Receptor
ALK
Androgen Receptor
Arrestin
ATP Citrate Lyase
ATPase
Beta Amyloid
CaMK
CETP
Cysteine Protease
E1/E2/E3 Enzyme
Epigenetic Reader Domain
FXR
GPX
HBV
HCV Protease
HER
Hexokinase
HIF/HIF Prolyl-Hydroxylase
Histone Demethylase
Histone Methyltransferase
HMG-CoA Reductase
HSV
Influenza Virus
Integrin
Interleukin
IκB/IKK
Kinesin
Lipid
Melatonin Receptor
Microtubule Associated
Monocarboxylate transporter
MRP
MTH1
NADPH
NO Synthase
NOD-like Receptor (NLR)
NOS
Nrf2
Nucleoside Antimetabolite/Analog
p38 MAPK
Parasite
PDE
PDK
PGE Synthase
P-gp
Potassium Channel
PROTAC Linker
PTEN
Raf
RANKL/RANK
Retinoid Receptor
ROR
Sigma receptor
Stearoyl-CoA Desaturase (SCD)
Telomerase
TNF
Topoisomerase
Transferase
Trk receptor
TRP/TRPV Channel
Tyrosinase
Tyrosine Kinases
UGT
Virus Protease