Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
Description | IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines. |
In vitro | IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress[1]. |
Synonyms | IRE1α kinase-IN-2 |
Molecular Weight | 504.517 |
Formula | C27H23F3N6O |
CAS No. | 1414938-21-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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IRE1α kinase-IN-2 1414938-21-8 IRE1α kinaseIN2 IRE1α kinase IN 2 IRE1alpha kinase-IN-2 IRE-1α kinase-IN-2 IRE1a kinase-IN-2 inhibitor inhibit