Search Result

Search Results for " il-15 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11634	IL-15-IN-1		IL Receptor , Interleukin
	IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells (IC50: 0.8 μM).		IL Receptor , Interleukin
T76892	Ordesekimab	AMG 714,PRV-015	IL Receptor
	Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interaction of IL-15 with the common gamma chain of the IL-2Rβ and IL...		IL Receptor
T1846	Y-320	Y320	IL Receptor , Lipase , Interleukin
	Y-320 is a new phenylpyrazoleanilide immunomodulator.		IL Receptor , Lipase , Interleukin
T77034	Inbakicept	N-803
	Inbakicept (ALT-803) is an IL-15 superagonist complex, consisting of IL-15 mutant and IL-15Rα-Fc fusion. Inbakicept magnifies anti-CD20 mAb-mediated NK-cell responses and antibody-dependent cellular cytotoxicity (ADCC). ...
T77156	Depemokimab
	Depemokimab (GSK-3511294) is a long-acting monoclonal antibody targeting IL-15, utilized in asthma research [1] [2].
T73014	NLRP3-IN-15
	NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of...
T78782	PROTAC BTK Degrader-6		BTK
	PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression of pro-inflammatory cytokines, such as IL-1β and IL-6 [1].		BTK
T79362	COX-2/15-LOX-IN-4		Lipoxygenase
	COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-i...		Lipoxygenase
T79361	COX-2/15-LOX-IN-3		Lipoxygenase
	COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respectively. This compound effectively suppresses LPS-induced cell...		Lipoxygenase
T60560	Anti-inflammatory agent 15
	Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial agent that can be used in the research of tuberculosis (TB). Anti-inflammatory agent 15 inhibits the growth of Mtb H37Rv and M299 with MIC50 of 2.3 a...
T79385	PDE1-IN-5
	PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demon...
T75092	STING agonist-24
	STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-...
T73330	JAK-IN-24
	JAK-IN-24, a JAK inhibitor, exhibits IC50 values of 0.534 nM and 24 nM in the presence of 4 μM and 1 mM ATP, respectively. Additionally, it effectively inhibits STAT5 phosphorylation induced by PBMC IL-15 with an IC50 of...
T75094	STING agonist-26
	STING agonist-23 (CF508), a non-nucleotide small-molecule STING agonist, activates STING, thereby enhancing the phosphorylation of STING, TBK1, and IRF3. This activation elevates the production of IFN-β, IL-6, CXCL-10, T...
T75093	STING agonist-25
	STING agonist-23 (CF505) is a non-nucleotide, small-molecule compound that stimulates STING, enhancing the phosphorylation of STING, TBK1, and IRF3. It elevates the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and ...
T75096	STING agonist-28
	STING agonist-23 (CF510) is a non-nucleotide, small-molecule activator of the STING pathway. It initiates the phosphorylation of STING, TBK1, and IRF3, enhancing the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and...
T75091	STING agonist-23
	STING agonist-23 (CF502) is a non-nucleotide, small-molecule stimulator of the STING pathway. Upon activation, it enhances the phosphorylation of STING, TBK1, and IRF3, leading to elevated levels of IFN-β, IL-6, CXCL-10,...
T83670	F1 TFA	Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide
	F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectivel...
T82189	HMGB1-IN-2
	HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces...
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30...
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...

Compounds

IL-15-IN-1

T11634

Synonym:

Target: IL Receptor, Interleukin

Ordesekimab

T76892

Synonym: AMG 714,PRV-015

Target: IL Receptor, Lipase, Interleukin

PROTAC BTK Degrader-6

Anti-inflammatory agent 15

Synonym: Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide

ß-Carboline-1-carboxylic acid

T71884

Synonym:

Target:

β-Defensin-4 (human) (trifluoroacetate salt)

LL-37 amide (trifluoroacetate salt)

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01461	IL-15RA & IL-15 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R f...
TMPY-04632	IL-15 Protein, Human, Recombinant	Human	E. coli
	IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1.
TMPJ-01462	IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)	Human	HEK293 Cells
	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R f...
TMPY-04049	IL-15 Protein, Human, Recombinant (His)	Human	E. coli
	IL-15 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P40933-1.
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells)	Human	HEK293 Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bi...
TMPK-00160	IL-15RA Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Interleukin-15 receptor alpha (IL-15R alpha) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelia...
TMPK-00159	IL-15RA Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin-15 receptor alpha (IL-15R alpha) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelia...
TMPY-06020	IL-15 & IL-15RA Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-15 & IL-15RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.9 kDa and the accession number is NP_002180.1&NP_000576.1.
TMPK-00321	IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated	Cynomolgus	HEK293 Cells
	IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.6 kDa and the accession number i...
TMPY-06531	IL-15 & IL-15RA Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-15 & IL-15RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.46 kDa and the accession number is P48346-1 & Q60819-1.
TMPY-06591	IL-15RA Protein, Mouse, Recombinant (aa 1-205, hFc)	Mouse	HEK293 Cells
	IL-15RA Protein, Mouse, Recombinant (aa 1-205, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.10 kDa and the accession number is Q60819-1.
TMPK-00320	IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is P14784.
TMPH-02441	IL-15 Protein, Rhesus macaque, Recombinant (His)	Rhesus	P. pastoris (Yeast)
	Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA. In neutrophils, stimula...
TMPY-00524	IL-7 Protein, Mouse, Recombinant	Mouse	E. coli
	IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.
TMPJ-00890	IL-13 Protein, Mouse, Recombinant (aa 26-131, His)	Mouse	HEK293 Cells
	IL-13 Protein, Mouse, Recombinant (aa 26-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 15-30 KDa and the accession number is P20109.
TMPJ-00154	IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells)	Mouse	HEK293 Cells
	Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, o...
TMPY-02809	IL-21 Protein, Canine, Recombinant	Canine	E. coli
	IL-21 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is Q6L7I9.
TMPY-04042	IL-7 Protein, Rat, Recombinant	Rat	E. coli
	IL-7 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is Q91Y32.
TMPY-01966	IL-17F Protein, Mouse, Recombinant	Mouse	E. coli
	IL-17F Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is Q7TNI7-1.
TMPJ-01339	IL-22 Protein, Mouse, Recombinant (E. coli)	Mouse	E. coli
	IL-22 Protein, Mouse, Recombinant (E. coli) is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is Q9JJY9.
TMPY-00803	Fibronectin Protein, Human, Recombinant (aa 607-1265, His)	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 607-1265, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.2 kDa and the accession number is P02751-15.
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63...
TMPJ-00239	IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc)	Mouse	HEK293 Cells
	The Interleukin-2 receptor gamma chain (IL-2 Rγ, CD132) of the high affinity functional mouse IL-2 receptor complex is a member the hematopoietin receptor family. It is expressed on most lymphocyte (white blood cell) pop...
TMPK-00084	IL-17C Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conser...
TMPJ-00832	Granzyme D/GZMD Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Granzyme D is a member of the granzyme family of the serine proteases which plays a role in the induction of apoptosis. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, b...
TMPJ-01316	IL-21 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, re...
TMPY-05562	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa and the accession number is P02751-15.
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 we...
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 we...