Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Y-320 is a new phenylpyrazoleanilide immunomodulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 236.00 | |
50 mg | In stock | $ 417.00 | |
100 mg | In stock | $ 619.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | Y-320 is a new phenylpyrazoleanilide immunomodulator. |
Targets&IC50 | IL-17 production:20-60 nM |
In vitro | Y-320 can inhibit the production of IFN-γ and TNF-α in mouse CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 monoclonal antibody. |
In vivo | Y-320 (administered orally at doses of 0.3-3 mg/kg) enhances the improvement of collagen-induced arthritis (CIA) in mice, concurrently reducing the expression levels of IL-17 mRNA within arthritic joints. Additionally, it has demonstrated therapeutic efficacy for CIA in crab-eating macaques. |
Synonyms | Y320 |
Molecular Weight | 505.01 |
Formula | C27H29ClN6O2 |
CAS No. | 288250-47-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 9 mg/mL (17.8 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Y-320 288250-47-5 Immunology/Inflammation Metabolism Interleukin Lipase IL Receptor Interleukin Related anticancer Y320 phenylpyrazoleanilide Y 320 G418 inhibit Apoptosis immunomodulator rheumatoid arthritis protein synthesis Inhibitor inhibitor