hyperalgesia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22518	5-BDBD		P2X Receptor
	5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.		P2X Receptor
T9685	DS-1971a		Sodium Channel
	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.		Sodium Channel
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others
T23498	UNC3230	UNC 3230	Others
	UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230(UNC 3230) also inhibits PIP4K2C.		Others
T21543	AP 18		TRP/TRPV Channel
	AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete ...		TRP/TRPV Channel
T21976	ONO-8130		Prostaglandin Receptor
	ONO-8130 is an orally available antagonist of EP1 receptor.		Prostaglandin Receptor
T6950	PNU-120596	NSC 216666	AChR
	PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.		AChR
T21983L	PKI 14-22 amide, myristoylated Acetate	PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)	PKA
	PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.		PKA
T12632	(R)-Mirtazapine	(R)-Org3770,(R)-6-Azamianserin	5-HT Receptor
	(R)-Mirtazapine ((R)-Org3770) is the R(-)-enantiomer of Mirtazapine, which has anti-injury sensory properties in an animal model of acute thermal hyperalgesia. (R)-Mirtazapine is an antagonist of 5-HT3 receptors and a po...		5-HT Receptor
T23076L	Nociceptin (1-7) acetate		Opioid Receptor
	Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity.		Opioid Receptor
T4236	AR-M 1000390 hydrochloride	ARM390 Hydrochloride,ARM-390 HCl	Opioid Receptor
	AR-M 1000390 hydrochloride (ARM-390 HCl) , also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensitization of the analgesic resp...		Opioid Receptor
TP1904L	FSLLRY-NH2 TFA(245329-02-6 free base)		Protease-activated Receptor
	FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in iso...		Protease-activated Receptor
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
T37610	AT-121		Opioid Receptor
	AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors...		Opioid Receptor
TP2277	Nocistatin(human)	Nocistatin (human)	Others
	Blocker of nociceptin-induced allodynia and hyperalgesia		Others
T23076	Nociceptin(1-7)	Nociceptin (1-7)	Others
	Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesia		Others
T15167	Draflazine	R-75231	Others
	Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carra...		Others
T80500	Jingzhaotoxin-X	JZTX-X	Potassium Channel
	Jingzhaotoxin-X (JZTX-X) selectively inhibits Kv4.2 and Kv4.3 potassium channels, resulting in prolonged mechanical hyperalgesia [1].		Potassium Channel
T21393	Ethopropazine Hydrochloride	Lysivane,Parphezein,Dibutil,Parfezin,Profenamine HCl,Pardisol
	Ethoproprazine hydrochloride is an butyrylcholinesterase inhibitor. It reduces extrapyramidal motor effects and used as an antidyskinetic, characteristic of Parkinson′s disease. It also alleviates thermal hyperalgesia in...
TP2276	Nocistatin (bovine)		Others
	endogenous peptide used to block nociceptin-induced allodynia and hyperalgesia		Others