hydroxylation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7692	2,4-DPD		HIF
	2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)		HIF
T11847L	Liarozole	R75251 dihydrochloride	P450 , Retinoid Receptor
	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...		P450 , Retinoid Receptor
T3S0804	Worenine	Worenin	Others
	Worenine (Worenin) is used in the a flurophore switched probe which aids in correction of an abasic site (AP site) caused by the removal of a damaged base in DNA.		Others
T9624	Iron chloride hexahydrate
	iron chloride hexahydrate promoted selective hydroxylation and chlorination of benzyl ketone derivatives for the construction of hetero-quaternary scaffolds.
T3696	Polygalaxanthone III		Others , P450
	Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.		Others , P450
T21653	1,4-DPCA		HIF/HIF Prolyl-Hydroxylase
	1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).		HIF/HIF Prolyl-Hydroxylase
T3397	Epmedin C	Baohuoside-VI,Epimedin C	Others
	Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteopor...		Others
T2S2211	Tenuifoliside C		Dehydrogenase
	Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].		Dehydrogenase
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
T3818	Fraxinol		Others , P450
	Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an...		Others , P450
TQ0121	VH-298		Others , HIF , Ligand for E3 Ligase
	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P...		Others , HIF , Ligand for E3 Ligase
T1055	Ifosfamide	NSC109724,Isophosphamide	DNA Alkylator/Crosslinker , DNA/RNA Synthesis
	Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...		DNA Alkylator/Crosslinker , DNA/RNA Synthesis
T4A2458	Resibufogenin	Bufogenin,Recibufogenin	Others
	1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological eff...		Others
T11277	FG 7142	ZK 39106,LSU-65	GABA Receptor
	FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...		GABA Receptor
T33370	Metyrapol	SU 5236,SU-5236,SU5236
	Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.
T32743	Licodione
	Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone.
T19394	L-hydroxylysine dihydrochloride	(2S,5R)-5-Hydroxylysine dihydrochloride	Others
	L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.		Others
T19610	(24S)-24,25-Dihydroxyvitamin D3	(24S)-24,25-Dihydroxycholecalciferol	Others
	(24S)-24,25-Dihydroxyvitamin D3 undergoes various levels of hydroxylation to form active vitamin D3 analogs.		Others
TMA2106	(-)-Sparteine		P450
	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.		P450
T19773	Diethyl bipy55'DC
	Diethyl bipy55'DC inhibits CP4H activity in cultured cells. The stability of collagen relies on post-translational modifications, the most prevalent being the hydroxylation of collagen strands by collagen prolyl 4-hydrox...