15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11538 | Hck-IN-1 | HIV Protease , Src , Hck | |
Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for w... | |||
T13186 | TL02-59 | Apoptosis , Src , Hck | |
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growt... | |||
T40594 | IHCK-37 | iHCK-37,ASN05260065 | |
iHCK-37 (ASN05260065) is a high-potency, selective inhibitor of Hck with a Ki value of 0.22 μM. It effectively inhibits HIV-1 viral replication, exhibiting an EC50 value of 12.9 μM. Primarily employed in chronic myeloid ... | |||
T2415 | PP121 | Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck | |
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM). | |||
T6217 | LFM-A13 | PLK , JAK , BTK | |
LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK. | |||
T61793 | HIV-IN-6 | HIV Protease | |
HIV-IN-6 is an HIV viral inhibitor that inhibits the replication of the HIV virus.HIV-IN-6 has anti-HIV viral activity and works by targeting Src family kinases (SFK) (e.g., Hck) that interact with the viral Nef protein. | |||
T6093 | AZD-7762 | AZD7762 | Chk |
AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. | |||
T72918 | JNJ-49095397 | RV568 | |
JNJ-49095397 (RV568), an inhaled narrow-spectrum kinase inhibitor (NSKI), targets the α and γ isoforms of p38 MAPK and the SRC kinase family, particularly haematopoietic kinase (HCK). Demonstrating potent anti-inflammato... | |||
T2640 | Rebastinib | DCC2036,DCC 2036,DCC-2036 | Apoptosis , FLT , Bcr-Abl , Src |
DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re... | |||
T79516 | BT424 | Src | |
BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1]. | |||
T38965 | EPQpYEEIPIYL | ||
EPQpYEEIPIYL, a phosphopeptide, is a ligand for the Src homology 2 (SH2) domain. It activates members of the Src family, such as Lck, Hck, and Fyn, through the binding interaction with SH2 domains. | |||
T13157L | TG 100801 Hydrochloride | VEGFR | |
TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PD... | |||
T13156 | TG 100572 | VEGFR | |
TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck,... | |||
T13156L | TG 100572 Hydrochloride | VEGFR , FGFR , PDGFR , Src | |
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, ... | |||
T13186L | TL02-59 dihydrochloride | Src | |
TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM). |