gli — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22089	HPI 1		Hedgehog/Smoothened
	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...		Hedgehog/Smoothened
T24159	IHR-1	IHR 1	Smo
	IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.		Smo
T15370	GANT 58	NSC 75503	Hedgehog/Smoothened
	GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).		Hedgehog/Smoothened
T3070	GANT 61	NSC 136476,GANT61	Hedgehog/Smoothened , Autophagy
	GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.		Hedgehog/Smoothened , Autophagy
T12710	Retagliptin Phosphate	SP 2086	Proteasome , DPP-4
	Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.		Proteasome , DPP-4
T28743	Seglitide acetate	MK 678,MK678,MK-678	Somatostatin
	Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor.		Somatostatin
T7369	Gemigliptin	LC15-0444	Proteasome , DPP-4
	Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)		Proteasome , DPP-4
T1529	Miglitol	BAY1099,BAY-m1099	Others
	Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.		Others
T0178	Saxagliptin hydrate	Onglyza hydrate,BMS-477118 hydrate	Proteasome , DPP-4
	Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).		Proteasome , DPP-4
T14130	Adomeglivant	LY2409021	Glucagon Receptor
	Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.		Glucagon Receptor
T77781	Lotiglipron	PF-07081532	Glucagon Receptor
	Lotiglipron (PF-07081532) is an orally active and potent GLP-1R agonist that reduces blood glucose and body weight and may be useful in the study of type 2 diabetes mellitus (T2DM) and obesity.		Glucagon Receptor
T8239	Cromoglicic acid		Others
	Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.		Others
T7217	Bexagliflozin	THR-1442,EGT1442,EGT0001442	SGLT
	Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively		SGLT
T1088	Repaglinide	AG-EE 388 ZW,AG-EE 623ZW	Potassium Channel , PPAR
	Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare...		Potassium Channel , PPAR
T1674	Nateglinide	A4166,Senaglinide	Potassium Channel , Proteasome , PPAR
	Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins...		Potassium Channel , Proteasome , PPAR
T5016	Tofogliflozin (hydrate)	Tofogliflozin hydrate,CSG-452 hydrate	SGLT , Reactive Oxygen Species , ROS
	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).		SGLT , Reactive Oxygen Species , ROS
T15385	Glibornuride		Potassium Channel
	Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.		Potassium Channel
T8493	Ingliforib	GPi 296,CP 368296	Phosphorylase
	Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties.		Phosphorylase
T67849	O-Desethyl Dapagliflozin	Empagliflozin-4	SGLT
	O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.		SGLT
T2316	Omarigliptin	MK-3102	Proteasome , DPP-4
	Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.		Proteasome , DPP-4