Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 65.00 | |
2 mg | In stock | $ 92.00 | |
5 mg | In stock | $ 138.00 | |
10 mg | In stock | $ 207.00 | |
25 mg | In stock | $ 413.00 | |
50 mg | In stock | $ 613.00 | |
100 mg | In stock | $ 873.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 147.00 |
Description | Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively |
In vivo | EGT1442 produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner. |
Animal Research | Prior to experiment initiation, 7-week old SHRSP rats were assigned to 3 groups of 15 males each, based on body weights. During this week, daily water consumption was determined in order to calculate appropriate drug concentrations for the drinking water. The following week (Day 1), rats were switched to a stroke-promoting diet containing reduced potassium and protein and elevated NaCl. Animals received water bottles containing either no compound, EGT1442 (3.0 mg/kg) or the sodium channel blocker amiloride (1.0 mg/kg). Body weights were measured 2 times per week, and dosages were adjusted weekly. Water consumption was likewise measured 2 times per week, while food consumption wasmeasured weekly. Daily values were estimated. Urine samples were analyzed by test strips once every two weeks. Additionally, all animals were observed twice daily and any abnormal findings were recorded. |
Synonyms | THR-1442, EGT1442, EGT0001442 |
Molecular Weight | 464.94 |
Formula | C24H29ClO7 |
CAS No. | 1118567-05-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (215.08 mM)
You can also refer to dose conversion for different animals. More
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Bexagliflozin 1118567-05-7 GPCR/G Protein SGLT THR-1442 EGT-1442 EGT 0001442 THR 1442 EGT-0001442 EGT1442 THR1442 EGT 1442 EGT0001442 inhibitor inhibit