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Catalog No. T7369   CAS 911637-19-9
Synonyms: LC15-0444, 吉格列汀酒石酸盐

Gemigliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)

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Gemigliptin, CAS 911637-19-9
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gemigliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Targets&IC50 DPP-4:7.25 nM(KD)
In vitro Gemigliptin attenuated vascular calcification and osteogenic trans-differentiation in vascular smooth muscle cells via multiple steps including downregulation of PiT-1 expression and suppression of reactive oxygen species generation, phospho-PI3K/AKT, and the Wnt signaling pathway[1].Gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells[2].
Cell Research Using immunohistochemical and Western blot analysis, Quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins[2].
Synonyms LC15-0444, 吉格列汀酒石酸盐
Molecular Weight 489.37
Formula C18H19F8N5O2
CAS No. 911637-19-9


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 122.5 mg/mL (250.33 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Choi S Y , Ryu H M , Oh E J , et al. Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells[J]. PLoS ONE, 2017, 12(7):e0180393. 2. Jung, Beom, Seo, et al. Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.[J]. Diabetes & metabolism journal, 2019.

Related compound libraries

This product is contained In the following compound libraries:
Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Diabetic Compound Library

Related Products

Related compounds with same targets
Azaleatin Gemigliptin Tartrate(911637-19-9 free base) Gemigliptin Anagliptin Teneligliptin hydrobromide Talabostat mesylate Sitagliptin phosphate Omarigliptin

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Gemigliptin 911637-19-9 蛋白酶体 泛素化 DPP-4 Proteasome Inhibitor LC15-0444 DPP Dipeptidyl Peptidase inhibit inhibitor