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Gemigliptin

Catalog No. T7369 CAS 911637-19-9

Synonyms: LC15-0444, 吉格列汀酒石酸盐

Gemigliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)

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Gemigliptin, CAS 911637-19-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gemigliptin is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Targets&IC50	DPP-4:7.25 nM(KD)
In vitro	Gemigliptin attenuated vascular calcification and osteogenic trans-differentiation in vascular smooth muscle cells via multiple steps including downregulation of PiT-1 expression and suppression of reactive oxygen species generation, phospho-PI3K/AKT, and the Wnt signaling pathway[1].Gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells[2].
Cell Research	Using immunohistochemical and Western blot analysis, Quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins[2].

Synonyms	LC15-0444, 吉格列汀酒石酸盐
Molecular Weight	489.37
Formula	C18H19F8N5O2
CAS No.	911637-19-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 122.5 mg/mL (250.33 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Choi S Y , Ryu H M , Oh E J , et al. Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells[J]. PLoS ONE, 2017, 12(7):e0180393. 2. Jung, Beom, Seo, et al. Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.[J]. Diabetes & metabolism journal, 2019.

Related compound libraries

This product is contained In the following compound libraries：

Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Diabetic Compound Library

Related Products

Related compounds with same targets

Azaleatin Gemigliptin Tartrate(911637-19-9 free base) Gemigliptin Anagliptin Teneligliptin hydrobromide Talabostat mesylate Sitagliptin phosphate Omarigliptin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gemigliptin 911637-19-9 蛋白酶体泛素化 DPP-4 Proteasome Inhibitor LC15-0444 DPP Dipeptidyl Peptidase inhibit inhibitor

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