dna-pk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2433	NU 7026	NU7026,DNA-PK Inhibitor II,LY293646	Apoptosis , ATM/ATR , DNA-PK , PI3K
	NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.		Apoptosis , ATM/ATR , DNA-PK , PI3K
T15789	LTURM34		DNA-PK , PI3K , PI4K
	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .		DNA-PK , PI3K , PI4K
T4339	YU238259		DNA-PK , Others
	YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.		DNA-PK , Others
T2461	PIK-90		DNA-PK , PI3K
	PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .		DNA-PK , PI3K
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
T3986	SF2523		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
	SF2523 is a highly selective and potent inhibitor.		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
T3541	CC-115	CC 115	DNA-PK , PI3K , mTOR
	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).		DNA-PK , PI3K , mTOR
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T79165	DNA-PK-IN-10		DNA-PK
	DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].		DNA-PK
T61751	DNA-PK-IN-3
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tum...
T9760	IC 86621		DNA-PK
	IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell...		DNA-PK
T62034	DNA-PK-IN-7
	DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).
T62191	DNA-PK-IN-5
	DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits the activity of DNA-PKcs, significantly reduces tumour DNA repair and induces apoptosis. DNA-PK-IN-5 improves the sensitivity of tumour tissue to radiothe...
T61857	DNA-PK-IN-4
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly imp...
T6557	KU-0060648	KU0060648	DNA-PK , PI3K , mTOR
	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.		DNA-PK , PI3K , mTOR
T62648	DNA-PK-IN-1
	DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.
T61633	DNA-PK-IN-2
	DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications i...
T61533	DNA-PK-IN-9
	DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1].
T61370	DNA-PK-IN-6
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 ampli...
T61828	DNA-PK-IN-8
	DNA-PK-IN-8 is a potent, selective, and orally active inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.8 nM. It displays synergistic antiproliferative effects across various cancer cel...