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LTURM34

Catalog No. T15789 CAS 1879887-96-3

LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .

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LTURM34, CAS 1879887-96-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .
Targets&IC50	PI4Kδ:8.5 μM, DNA-PK:34 nM, PI3Kβ:5.8 μM
In vitro	LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .

Molecular Weight	414.48
Formula	C24H18N2O3S
CAS No.	1879887-96-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/mL (144.76 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library Anti-Cancer Active Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

DMNB AZD-7648 OSI-027 SF2523 CC-115 ETP-45658 PIK-75 hydrochloride PI-3065

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Keywords

LTURM34 1879887-96-3 DNA损伤和修复 PI3K/Akt/mTOR信号通路 DNA-PK PI4K PI3K LTURM 34 Inhibitor LTURM-34 inhibit DNA-dependent protein kinase inhibitor

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