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LTURM34

LTURM34
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Purity:99.91%
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LTURM34

Catalog No. T15789Cas No. 1879887-96-3
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .
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Pack SizePrice/USDAvailabilityQuantity
5 mg$64In Stock
10 mg$113In Stock
25 mg$247In Stock
50 mg$428In Stock
100 mg$639In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Product Introduction

Bioactivity
Description
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .
In vitro
LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .
Chemical Properties
Molecular Weight414.48
FormulaC24H18N2O3S
Cas No.1879887-96-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/mL (144.76 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4127 mL12.0633 mL24.1266 mL120.6331 mL
5 mM0.4825 mL2.4127 mL4.8253 mL24.1266 mL
10 mM0.2413 mL1.2063 mL2.4127 mL12.0633 mL
20 mM0.1206 mL0.6032 mL1.2063 mL6.0317 mL
50 mM0.0483 mL0.2413 mL0.4825 mL2.4127 mL
100 mM0.0241 mL0.1206 mL0.2413 mL1.2063 mL

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