Powder: -20°C for 3 years
In solvent: -80°C for 2 years
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .
Description | LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K . |
Targets&IC50 | PI4Kδ:8.5 μM, DNA-PK:34 nM, PI3Kβ:5.8 μM |
In vitro | LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) . |
Molecular Weight | 414.48 |
Formula | C24H18N2O3S |
CAS No. | 1879887-96-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 60 mg/mL (144.76 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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LTURM34 1879887-96-3 DNA损伤和修复 PI3K/Akt/mTOR信号通路 DNA-PK PI4K PI3K LTURM 34 Inhibitor LTURM-34 inhibit DNA-dependent protein kinase inhibitor