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SF2523

Catalog No. T3986 CAS 1174428-47-7

SF2523 is a highly selective and potent inhibitor.

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SF2523, CAS 1174428-47-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 672.00
500 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98.06%

Purity: 97.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SF2523 is a highly selective and potent inhibitor.
Targets&IC50	mTOR:280 nM, PI3Kγ:158 nM, BRD4:241 nM, PI3Kα:34 nM, DNA-PK:9 nM
In vitro	Treatment with SF2523 leads to a reduction in the protein levels of MYCN and Cyclin D1, targets of MYCN. It also impedes AKT activation by preventing the phosphorylation at Ser473 and results in the removal of BRD4 from MYCN promoter sites. SF2523 exhibits a strong interaction with full-length BRD4 (Kd=140 nM), showing a similar affinity for BRD4's first bromodomain (BD1) (Kd=150 nM) but a weaker affinity for its second bromodomain (BD2) (Kd=710 nM). When comparing the binding affinities of SF2523 to bromodomains (BDs) of different proteins, it demonstrates equal binding to BDs of BRD4, BRD2, and BRD3; a moderate binding to BDs of CECR2 and BRDT; and significantly weaker binding to other BDs[1].
In vivo	Treatment with SF2523 significantly reduces tumor volume without causing gross toxicity in mice, as evidenced by stable body weight. Furthermore, tumors in mice treated with SF2523 exhibit notably lower levels of MYCN, pAKT, and Cyclin D1 compared to those in mice treated with the vehicle[1].

Molecular Weight	371.41
Formula	C19H17NO5S
CAS No.	1174428-47-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (26.92 mM)

References and Literature

1. Andrews FH, et al. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Kinase Inhibitor Library Neuronal Differentiation Compound Library Epigenetics Compound Library Anti-Obesity Compound Library Chromatin Modification Compound Library Cancer Cell Differentiation Compound Library Neural Regeneration Compound Library Oxidation-Reduction Compound Library

Related Products

Related compounds with same targets

CC-115 PI-3065 NU 7026 KU-0060648 ETP-45658 (Rac)-Nedisertib DMNB PI-103

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SF2523 1174428-47-7 Chromatin/Epigenetic DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK Epigenetic Reader Domain PI3K mTOR SF 2523 SF-2523 Inhibitor Phosphoinositide 3-kinase DNA-dependent protein kinase inhibit inhibitor

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