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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4197 | HZ-1157 | HZ1157,DHFR-inhibitor | HCV Protease |
HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease. | |||
T3693 | DHFR-IN-3 | 7-bromoquinazoline-2,4-diamine | Others |
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical. | |||
T36692 | Fanotaprim | DHFR | |
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o... | |||
T61159 | Antibacterial agent 26 | Antibacterial | |
Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM). | |||
T61486 | DHFR-IN-4 | DHFR | |
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer. | |||
T19858 | Brodimoprim | DHFR , Antibacterial | |
Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile. | |||
T0849 | Pyrimethamine | Pirimecidan,RP 4753,Pirimetamin | DHFR , Antifolate , Parasite |
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug. | |||
T1485 | Methotrexate | NCI-C04671,WR19039,Amethopterin,CL14377 | Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate |
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... | |||
T6120 | Pralatrexate | Folotyn,10-Propargyl-10-deazaaminopterin | Apoptosis , DHFR , Antifolate , TAM Receptor |
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act... | |||
T27002 | CH-1504 | CH 1504,MobileTrex | |
CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis. | |||
T40619 | Tetroxoprim | HE 781,Tetroxoprim | |
Tetroxoprim is an antimicrobial DHFR inhibitor. | |||
T82570 | DHFR-IN-11 | ||
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M. tuberculosis DHFR enzyme, reflected in an IC50 value of 5.70 μM [1]. | |||
T73328 | DHFR-IN-5 | ||
DHFR-IN-5, an orally active and potent inhibitor of dihydrofolate reductase (DHFR), exhibits a K_i value of 0.54 nM against the quadruple mutant Plasmodium falciparum DHFR, demonstrating anti-malarial activity. | |||
T82571 | DHFR-IN-10 | ||
DHFR-IN-10 (compound 4c) is a potent inhibitor of dihydrofolate reductase (DHFR), displaying an inhibition concentration half-maximum (IC50) of 4.21 μM against Mycobacterium tuberculosis DHFR enzyme and demonstrates stro... | |||
T60726 | OYYF-175 | ||
OYYF-175 is an antimicrobial antifolate. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. OYYF-175 is an inhibitor of dihydrofolate reductas... | |||
T61272 | EGFR/HER2-IN-7 | ||
EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate re... | |||
T61229 | VEGFR-2/DHFR-IN-2 | ||
VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, wi... | |||
T63379 | DHFR-IN-1 | ||
DHFR-IN-1 is a selective and potent inhibitor of DHFR (dihydrofolate reductase) (IC50: 40.71 nM). DHFR-IN-1 exhibited some antifungal activity and good antibacterial activity against Gram-positive and Gram-negative bacte... | |||
T25981 | Pralatrexate, (S)- | ||
Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ... | |||
T25980 | Pralatrexate, (R)- | ||
Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ... |