Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.
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Description | Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis. |
Molecular Weight | 477.47 |
Formula | C23H23N7O5 |
CAS No. | 1320211-69-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Pralatrexate, (S)- 1320211-69-5 Pralatrexate, (S) inhibitor inhibit