crbn — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8824	CRBN modulator-1	WUN29654	Others , Ligand for E3 Ligase
	CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.		Others , Ligand for E3 Ligase
T9360	CRBN ligand-9	2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione	Ligand for E3 Ligase
	CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.		Ligand for E3 Ligase
T35479	CRBN-6-5-5-VHL
	Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. ...
T18604	PROTAC CRBN Degrader-1		Others
	PROTAC CRBN Degrader-1 is a chemical compound consisting of a cereblon (CRBN) ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group. It functions as a cereblon (CRBN) degrader[1].		Others
T18787	TD-165		Others , Ligand for E3 Ligase
	TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].		Others , Ligand for E3 Ligase
T16363	NVP-2		Apoptosis , CDK
	NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD...		Apoptosis , CDK
T9370	DCBP-1		Epigenetic Reader Domain , Ligand for E3 Ligase
	dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.		Epigenetic Reader Domain , Ligand for E3 Ligase
T10765	Eragidomide	CC-90009,Cereblon modulator 1	Apoptosis , Ligand for E3 Ligase , Molecular Glues
	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.		Apoptosis , Ligand for E3 Ligase , Molecular Glues
T9291	Thalidomide-5-OH	2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione	Others , Ligand for E3 Ligase
	Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a link...		Others , Ligand for E3 Ligase
T7791	Iberdomide	CC-220	Apoptosis , Ligand for E3 Ligase
	Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).		Apoptosis , Ligand for E3 Ligase
T40016	Thalidomide-NH-CH2-COOH	2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine	Ligand for E3 Ligase
	Thalidomide-NH-CH2-COOH is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.		Ligand for E3 Ligase
T40503	Thalidomide-5-methyl		Ligand for E3 Ligase
	Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.		Ligand for E3 Ligase
T14893	CC-885		Others , Ligand for E3 Ligase
	CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.		Others , Ligand for E3 Ligase
T39910	Desmorpholinyl Navitoclax-NH-Me	Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me	BCL
	Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].		BCL
T40012	Thalidomide-CH2CONH-C2-COOH		Others
	Thalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.		Others
T40013	Thalidomide-O-CH2CONH-CH2COOH		Others
	Thalidomide-O-CH2CONH-CH2COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.		Others
T13721	Homo-PROTAC cereblon degrader 1		Others , Ligand for E3 Ligase
	Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.		Others , Ligand for E3 Ligase
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
T18066	Lenalidomide-OH		Ligand for E3 Ligase
	Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protei...		Ligand for E3 Ligase
T40001	Pomalidomide-C6-COOH		Others
	Pomalidomide-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.		Others