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Homo-PROTAC cereblon degrader 1

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Catalog No. T13721Cas No. 2244520-98-5

Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.

Homo-PROTAC cereblon degrader 1

Homo-PROTAC cereblon degrader 1

😃Good
Purity: 98.3%
Catalog No. T13721Cas No. 2244520-98-5
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$71In StockIn Stock
2 mg$98In StockIn Stock
5 mg$172In StockIn Stock
10 mg$297In StockIn Stock
25 mg$455In StockIn Stock
50 mg$728In StockIn Stock
100 mg$1,160In StockIn Stock
200 mg$1,560InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.3%
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Product Introduction

Bioactivity
Description
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
In vitro
Homo-PROTAC cereblon degrader 1 (0-1 μM, 16 hours) effectively reduces Cereblon protein levels in the multiple myeloma cell line NCI-H929. Experimental results indicate that the effect is observed at a concentration of 10 nM after 16-hour incubation. The degradation efficiency reaches its peak at concentrations between 100 nM and 1 μM. However, when the concentration is further increased to 100 μM, the degradation of Cereblon is completely inhibited [1].
When MM1S cells were treated with Homo-PROTAC cereblon degrader 1 (100 nM, 0-24 hours), cereblon protein levels decreased within 15 minutes and peaked at 6 hours [1].
The effects of homo-PROTAC cerebrone degrader 1 (0-10 μM, 4 days) on the proliferation of palomidomide-sensitive multiple myeloma cell lines MM1S, NCI-H929, LP-1, KMS27, and RPMI 8226 were investigated. The results showed that Homo-PROTAC cereblon degrader 1 had little effect on the proliferation of the cells at concentrations of ≤1 μM [1].
Chemical Properties
Molecular Weight660.63
FormulaC32H32N6O10
Cas No.2244520-98-5
SmilesO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCNC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4
Relative Density.1.527 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (302.74 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.57 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5137 mL7.5685 mL15.1371 mL75.6853 mL
5 mM0.3027 mL1.5137 mL3.0274 mL15.1371 mL
10 mM0.1514 mL0.7569 mL1.5137 mL7.5685 mL
20 mM0.0757 mL0.3784 mL0.7569 mL3.7843 mL
50 mM0.0303 mL0.1514 mL0.3027 mL1.5137 mL
100 mM0.0151 mL0.0757 mL0.1514 mL0.7569 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PROTACsInhibitorinhibitHomo-PROTAC cereblon degrader 1HomoPROTAC cereblon degrader 1Homo PROTAC cereblon degrader 1Cereblon
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