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Eragidomide

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Purity:99.41%

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COA HPLC HNMR

Eragidomide

Catalog No. T10765Cas No. 1860875-51-9

Dicyclanil is an insect growth regulator with a chemical structure similar to that of cyclopromazine.

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$79	In Stock
10 mg	$143	In Stock
25 mg	$298	In Stock
50 mg	$490	In Stock
100 mg	$725	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Product Introduction

Bioactivity

Description	Dicyclanil is an insect growth regulator with a chemical structure similar to that of cyclopromazine.
In vitro	Eragidomide demonstrated potent antiproliferative activity in 10 of 11 cell lines (e.g. NB4, U937, KG-1, MOLM-13, HL60 cells)with much less effect on the cell viability of PBMCs and THLE-2. The antiproliferative effect of Eragidomide is associated with apoptosis induction in all tested AML cell lines except OCI-AML3[1].
In vivo	In NOD/SCID mice, heterogeneous responses to the Eragidomide treatment (2.5mg/kg BID for 4 weeks) were observed. Of 35 AML samples tested, 16 were highly responsive to Eragidomide with >75% reduction of AML engraftment, 10 showed moderate response between 45% and 75% reductions, and 9 showed reductions of <25%. AML is clinically characterized by the accumulation of blasts that are impaired for differentiation and maturation. Eragidomide induced myeloid differentiation of AML blasts in the Eragidomide responders[3].
Alias	CC-90009, Cereblon modulator 1

Chemical Properties

Molecular Weight	461.85
Formula	C22H18ClF2N3O4
Cas No.	1860875-51-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 240 mg/mL (519.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1652 mL	10.8260 mL	21.6521 mL	108.2603 mL
5 mM	0.4330 mL	2.1652 mL	4.3304 mL	21.6521 mL
10 mM	0.2165 mL	1.0826 mL	2.1652 mL	10.8260 mL
20 mM	0.1083 mL	0.5413 mL	1.0826 mL	5.4130 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL	2.1652 mL
100 mM	0.0217 mL	0.1083 mL	0.2165 mL	1.0826 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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