Search Result

Search Results for " clp "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9179	CLP-3094	2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP...		Androgen Receptor
T5444	CLP290	CLP-290	Potassium Channel
	CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.		Potassium Channel
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T70604	ClpB-IN-1		Antibacterial
	ClpB-IN-1 is a potential antimicrobial agent.ClpB-IN-1 is a potent ClpB inhibitor.		Antibacterial
T77652	SARS-CoV-2 3CLpro-IN-20		Antiviral , SARS-CoV
	SARS-CoV-2 3CLpro-IN-20 is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM,).SARS-CoV-2 3CLpro-IN-20 has potential antiviral activity.		Antiviral , SARS-CoV
T79659	SARS-CoV-2 3CLpro-IN-16		SARS-CoV
	SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.		SARS-CoV
T79676	SARS-CoV-2 3CLpro-IN-21		Virus Protease
	SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 μM. Additionally, it exhibits inhibitory activity against SARS-CoV-...		Virus Protease
T72370	SARS-CoV-2 3CLpro-IN-6
	SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor targeting the SARS-CoV-2 3CL protease, demonstrating potent inhibitory activity with an IC50 of 4.9 μM. It is utilized in the research of coronavirus disease 2019...
T79661	SARS-CoV-2 3CLpro-IN-18		SARS-CoV
	SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent inhibitor of SARS-CoV-2 3CLpro with an IC50 of 0.478 μM. It demonstrates inhibition of SARS-CoV-2 in Vero E6 cells, with an EC50 of 2.499 μM, and exhibits low cytotoxic...		SARS-CoV
T71714	HClpP-activator-D9
	hClpP-activator-D9 is a novel potent and species-selective activator of human ClpP (hClpP).
T61774	SARS 3CLpro-IN-1
	SARS 3CLpro-IN-1 (Compound 3b) is a stereo-specific SARS 3CL protease inhibitor that belongs to the octahydroisochromene scaffold. It demonstrates inhibition against the P1 site imidazole, with an IC50 value of 95 μM [1]...
T72313	SARS-CoV-2 3CLpro-IN-11
	SARS-CoV-2 3CLpro-IN-11(11d) is a broad-spectrum antiviral compound that effectively inhibits the SARS-CoV-2 3CL protease, achieving an IC50 of 140 nM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 and...
T72364	SARS-CoV-2 3CLpro-IN-5		SARS-CoV
	SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), exhibiting potent inhibitory activity with an IC50 of 3.8 nM and demonstrating 9.0% oral bioavailability (BA). It is utilized in the...		SARS-CoV
T74807	SARS-CoV-2 3CLpro-IN-13
	SARS-CoV-2 3CLpro-IN-13 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating significant anti-coronavirus activity with an IC50 value of 21 nM [1].
T79462	SARS-CoV-2 3CLpro-IN-14		SARS-CoV
	SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μM and exhibits minimal cytotoxicity, having a CC50 greater ...		SARS-CoV
T72371	SARS-CoV-2 3CLpro-IN-7
	SARS-CoV-2 3CLpro-IN-7 is a reversible covalent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an inhibitory concentration (IC50) value of 1.4 µM.
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This partic...
T62734	SARS-CoV-2 3CLpro-IN-4
	SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a multifunctional inhibitor of SARS CoV-2 3CLpro, exhibiting antiviral, antibacterial, and antifungal activities.
T63679	SARS-CoV-2 3CLpro-IN-3
	SARS-CoV-2 3CLpro-IN-3 is a SARS CoV-2 3CLpro inhibitor that exhibits antiviral, antibacterial, and antifungal effects.
T72312	SARS-CoV-2 3CLpro-IN-10
	SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 190 nM, and demonstrates varied efficiency against other coronaviruses with IC50 values of 790 nM for SARS-CoV...
T80657	SARS-CoV-2 3CLpro-IN-15		Virus Protease
	SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral replication and transcription. It is instrumental in the id...		Virus Protease
T79660	SARS-CoV-2 3CLpro-IN-17		SARS-CoV
	Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].		SARS-CoV
T79376	SARS-CoV-2 3CLpro-IN-19		SARS-CoV
	SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of 0.7 μM. It demonstrates broad-spectrum efficacy against inf...		SARS-CoV
T63385	SARS-CoV-2 3CLpro-IN-2
	SARS-CoV-2 3CLpro-IN-2 is a potent inhibitor of the 3CL protease pair and has shown research potential for SARS-CoV-2 disease.
T23818	BPU-11	Biphenyl Urea 11	Others
	BPU-11 (Biphenyl Urea 11) is an HCN4 CLP ligand that acts by modulating channel function and completely abolishing the cAMP-induced shift in V1/2.		Others
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T35081	VU0486321	VU 0486321,VU-0486321
	VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/min/kg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).
T78803	SIRT5 inhibitor 7		Sirtuin
	SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating protein succinylation and attenuating pro-inflammatory cytokine release. It demo...		Sirtuin

Compounds

CLP-3094

T9179

Synonym: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE

Target: Androgen Receptor

CLP290

T5444

Synonym: CLP-290

Target: Potassium Channel

CLP257

T14984

Synonym:

Target: Potassium Channel

ClpB-IN-1

T70604

Synonym:

Target: Antibacterial

SARS-CoV-2 3CLpro-IN-20

T77652

Synonym:

Target: Antiviral, SARS-CoV

SARS-CoV-2 3CLpro-IN-16

T79659

Synonym:

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-21

T79676

Synonym:

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-6

T72370

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-18

SARS-CoV-2 3CLpro-IN-11

T72313

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-5

T72364

Synonym:

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-13

T74807

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-14

T79462

Synonym:

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-7

T72371

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-1

T63537

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-4

T62734

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-3

T63679

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-10

T72312

Synonym:

Target:

SARS-CoV-2 3CLpro-IN-15

T80657

Synonym:

Target: Virus Protease

SARS-CoV-2 3CLpro-IN-17

T79660

Synonym:

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-19

T79376

Synonym:

Target: SARS-CoV

SARS-CoV-2 3CLpro-IN-2

Synonym: Biphenyl Urea 11

Target: Others

Syk Inhibitor II hydrochloride

Synonym: VU 0486321,VU-0486321

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00582	Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
TMPH-00581	ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His) is expressed in E. coli expressio...
TMPH-00408	ClpP Protein, Clostridium botulinum, Recombinant (His & SUMO)	Clostridium botulinum	E. coli
	ClpP Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-02760	CALML3 Protein, Human, Recombinant (His)	Human	E. coli
	Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a ...
TMPH-00209	CLPP2 Protein, Borrelia burgdorferi, Recombinant (His & Myc)	Borrelia burgdorferi	E. coli
	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
TMPH-02577	CHID1 Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vi...
TMPH-01083	CHID1 Protein, Human, Recombinant (His)	Human	E. coli
	Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vi...
TMPH-01176	CSRP3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-01926	S100A10 Protein, Human, Recombinant (His)	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-02846	CLPS Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CLPS Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 11.5 kDa and the accession number is P04118.
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPY-00084	CLPS Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	CLPS Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.9 kDa and the accession number is P17084.
TMPY-05752	SARS-CoV-2 3CLpro/3C-like protease Protein (His)	SARS-CoV-2	Baculovirus Insect Cells
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPJ-01449	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant	SARS-CoV-2	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precur...
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPY-05727	SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)	SARS-CoV-2	E. coli
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPJ-01448	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)	2019-nCoV	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precur...
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPH-03712	Clp1 Protein, Xenopus laevis, Recombinant (His)	Xenopus laevis	E. coli
	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated mo...
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPY-00819	HAPLN1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Hyaluronan (HA) is a high MW glycosaminoglycan significantly involved in the formation and stability of extracellular matrix via its association with specific HA-binding proteins. HAPLN1, also known as CRTL1 (Cartilage L...
TMPY-02125	CCL6 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Chemokine (C-C motif) ligand 6 (CCL6), also known as C-C chemokine C10 has only been identified in rodents, which is a small cytokine belonging to the CC chemokine family, beta-chemokine subfamily. C-C chemokine C10 is i...