cdks — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17143	Toyocamycin	Vengicide	Apoptosis , Others , IRE1 , Antibiotic , Antifungal
	Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.		Apoptosis , Others , IRE1 , Antibiotic , Antifungal
T8819	SU-9516		CDK
	SU9516 is a selectively potent ATP-competitive inhibitor of CDKs.		CDK
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T5533	MC180295	(rel)-MC180295	CDK
	MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.		CDK
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T6837	Flavopiridol	L868275,Alvocidib,NSC 649890 HCl,HMR-1275	Apoptosis , HIV Protease , CDK , Autophagy
	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun...		Apoptosis , HIV Protease , CDK , Autophagy
T6177	PF-562271 besylate	PF-00562271 Besylate	FAK , PYK2 , CDK
	PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc...		FAK , PYK2 , CDK
T21768	PF-562271 hydrochloride	PF-562271 HCl	FAK , PYK2 , CDK
	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...		FAK , PYK2 , CDK
T2615	Flavopiridol hydrochloride	Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl	HIV Protease , CDK , Autophagy
	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of ...		HIV Protease , CDK , Autophagy
T16359	NU6140		CDK , Aurora Kinase
	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e...		CDK , Aurora Kinase
T10745	CDK9-IN-7		CDK
	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).		CDK
T6458	CYC-116		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ...		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
T23093	NSC 693868		Others
	CDKs and GSK-3 inhibitor		Others
T71121	Milciclib maleate
	Milciclib maleate is an inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA).
T2653	SB1317	TG02	FLT , JAK , CDK
	SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).		FLT , JAK , CDK
T16784	Roniciclib	BAY 1000394	CDK
	Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) v...		CDK
T28532	RGB-286147
	RGB-286147 is a potent, selective, ATP-competitive Cdks inhibitor.
T70707	Paullone
	Paullone is an inhibitor of cyclin-dependent kinases (CDKs). The CDKs are a family of protein kinases that are involved in regulation of the cell cycle.
T41019	Histone H1-derived Peptide	Histone H1-derived Peptide
	Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs).
T62943	ZLWT-37
	ZLWT-37 is a potent, orally active inhibitor of CDKs, acting on CDK9 (IC50: 0.002 μM) and CDK2 (IC50: 0.054 μM). ZLWT-37 is capable of blocking the cell cycle of HCT116 cells in G2/M phase and apoptosis.