brk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39772	BRK inhibitor P21d hydrochloride	BRK inhibitor P21d hydrochloride
	BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BR...
T17098	Tilfrinib		BTK
	Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.		BTK
T69980	XMU-MP-2		BTK , Protease
	XMU-MP-2 is a potent and selective protease inhibitor with anticancer activity that inhibits the growth of oncogenic BRK-driven tumors in a mouse xenograft model.		BTK , Protease
T16853	SB-633825		BTK
	SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively).		BTK
T41169	P21d hydrochloride
	P21d hydrochloride is a potent and selective breast tumor Ki nase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B Ki nase and Lck. Downregulates SNAIL protein, restores E-cadherin exp...
T67693	PF-6689840
	PF-6689840 is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays; inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.25 uM; dem...
T70424	EBI-907
	EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also...
T1835	Ibrutinib	PCI-32765	Tyrosine Kinases , Src , BTK , Ligands for Target Protein for PROTAC
	Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T13564L2	AZ7550 trimesylate salt	AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)	MLK
	AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.		MLK
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13564L	AZ7550 hydrochloride	AZ7550 hydrochloride (1421373-99-0 free base)	EGFR , IGF-1R
	AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).		EGFR , IGF-1R

Compounds

BRK inhibitor P21d hydrochloride

T39772

Synonym: BRK inhibitor P21d hydrochloride

Target: BTK, Protease

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

AZ7550 trimesylate salt

T13564L2

Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)

Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite

AZ7550 hydrochloride

T13564L

Synonym: AZ7550 hydrochloride (1421373-99-0 free base)

Target: EGFR, IGF-1R

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04377	Brk Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Brk Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 78 kDa and the accession number is Q13882-1.
TMPY-04440	Brk Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus Insect Cells
	Brk Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 79.8 kDa and the accession number is Q64434.
TMPY-01059	BMPR2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873.
TMPY-00683	BMPR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	BMPR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is Q13873.