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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2377 | Pilaralisib analogue | XL147 analogue,SAR245408 | Apoptosis , DNA-PK , PI3K |
Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ. | |||
T3576 | CPI-455 analogue | CPI-455 analogue | Others |
CPI-455 analogue (CPI-455 analogue) is an analogue of CPI-455 which is a KDM5 inhibitor. | |||
T12444 | Phentolamine Analogue 1 | Adrenergic Receptor | |
Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic. | |||
T7944 | VPS34 inhibitor 1 (Compound 19, PIK-III analogue) | PIK-III analogue | PI3K |
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM) | |||
T1826 | PI3K-IN-1 | Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 | DNA-PK , PI3K |
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. | |||
T2647 | IDO5L | INCB024360 analogue,INCB14943 | IDO , Indoleamine 2,3-Dioxygenase (IDO) |
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM). | |||
T3076 | GLPG0634 analog | GLPG0634 analogue | Tyrosine Kinases , JAK |
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively. | |||
T6921 | ONO-4059 analog | ONO-4059 analogue,ONO-WG-307,GS-4059 analog | Apoptosis , BTK |
ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1. | |||
T6705 | TIC10 Isomer | ONC201 isomer,TIC10 Analogue | Others |
TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv... | |||
T68855 | Hymenialdisine Analogue #1 | ||
Hymenialdisine Analogue #1 is the indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micro... | |||
T22633 | CCT251545 analogue, Compound 51 | Others | |
CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. ... | |||
T1806 | IDO-IN-7 | NLG919,Navoximod,NLG-919 analogue,GDC-0919 | Indoleamine 2,3-Dioxygenase (IDO) |
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor. | |||
T19616 | D-phenylalanine analogue | (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid | Others |
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, exhibits the capacity to adopt beta-bend and helical structures, facilitating a preferred side-chain orientation within th... | |||
T11393 | GET73 | Gamma hydroxybutyric acid analogue,GET 73 | GluR |
GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. | |||
T11935 | Macitentan (n-butyl analogue) | Others | |
Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros... | |||
T74641 | Rezivertinib analogue 1 | ||
Rezivertinib analogue 1, a process impurity of osimertinib mesylate, serves as a research tool in the study of non-small cell lung cancer (NSCLC) [1]. | |||
T81993 | Kadsurin A analogue-1 | ||
Kadsurin A Analogue-1 (Compound 8), a lignan, can be extracted from Piper argyrophylum [1]. | |||
T11549 | Helioxanthin 8-1 | Helioxanthin analogue 8-1 | Others |
Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM. | |||
TNU0045 | β-D-Ribofuranose analogue 1 | ||
Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Thio-nucleosides; Amino nucleosides; Protected nucleosides w/NH2/OH open | |||
T19858 | Brodimoprim | DHFR , Antibacterial | |
Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile. |