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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-med... | |||
T37475 | Cyclic ADP-Ribose (ammonium salt) | cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) | |
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second mes... | |||
T19253 | Cyclic ADP-ribose | cADPR | Calcium Channel |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med... | |||
T37803 | 8-bromo-Cyclic ADP-Ribose (sodium salt) | ||
Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, w... | |||
T10247 | Adenosine 5'-diphosphoribose sodium | Adenosine 5'-diphosphoribose sodium,ADP ribose sodium | Endogenous Metabolite , TRP/TRPV Channel , Autophagy |
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent ... | |||
T50098 | TIQ-A | PARP | |
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m... | |||
T22749 | DR2313 | DR 2313 | PARP |
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective. | |||
T6842 | G007-LK | PARP , Wnt/beta-catenin | |
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively. | |||
T15639 | K-756 | PARP , Wnt/beta-catenin | |
K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectively). | |||
T8964 | G244-LM | Others , PARP | |
G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling. | |||
T16761 | RK-287107 | Others , PARP | |
RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively). | |||
T21524 | 4-amino-1,8-Naphthalimide | PARP | |
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM | |||
T6197 | PJ34 | PARP | |
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. | |||
T6181 | UPF 1069 | PARP | |
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. | |||
T6578 | ME0328 | PARP | |
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. | |||
T2484 | AZD-2461 | PARP | |
AZD2461 is a novel PARP inhibitor. | |||
T6768 | AZ6102 | PARP , Wnt/beta-catenin | |
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. | |||
T3168 | MN-64 | MN64 | Others , PARP , Wnt/beta-catenin |
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. | |||
T1807 | JW 55 | JW55 | PARP , Wnt/beta-catenin |
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). | |||
T8184 | Fucosterol | PARP , Endogenous Metabolite , PPAR | |
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression. |