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UPF 1069

Catalog No. T6181 CAS 1048371-03-4

UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.

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UPF 1069, CAS 1048371-03-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 42.00
10 mg	In stock	$ 66.00
25 mg	In stock	$ 125.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 329.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.88%

Purity: 98.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
Targets&IC50	PARP2:0.3 μM
In vitro	UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM. [1]
In vivo	In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. [1]

Molecular Weight	279.29
Formula	C17H13NO3
CAS No.	1048371-03-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.9 mg/mL (100 mM)

References and Literature

1. Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Epigenetics Compound Library NO PAINS Compound Library Anti-Aging Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library Anti-Prostate Cancer Compound Library

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G244-LM PARP10-IN-2 OUL232 Veliparib dihydrochloride BGP-15 Lupiwighteone Iniparib AZD5305

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UPF 1069 1048371-03-4 Chromatin/Epigenetic DNA Damage/DNA Repair PARP UPF1069 inhibit Inhibitor poly ADP ribose polymerase UPF-1069 inhibitor

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