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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10151 | 5-Lipoxygenase-In-1 | Lipoxygenase | |
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor. | |||
T8260 | 4',5-Dihydroxyflavone | Lipoxygenase , Glucosidase | |
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM). | |||
T8356 | FPL 62064 | Lipoxygenase , COX | |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively). | |||
T5714 | 5-O-Demethylnobiletin | 5-DEMETHYLNOBILETIN | Leukotriene Receptor , Lipoxygenase |
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. | |||
T3S0153 | Xanthatin | Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial | |
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr... | |||
TN2330 | Phenethyl ferulate | Caffeic Acid 3-Methyl Phenethyl Ester | Lipoxygenase , COX |
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a... | |||
T6S0413 | Pectolinarigenin | Pectolinaringenin | Others , Lipoxygenase , COX |
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T75122 | 5-Lipoxygenase-IN-3 | ||
5-Lipoxygenase-IN-3 (Compound 14), with an IC50 of less than 1 μM, serves as an inhibitor of 5-Lipoxygenase. This compound is utilized in the research of inflammatory diseases, cancer, stroke, and Alzheimer's disease [1]... | |||
T16802 | Lonapalene | RS4317 | Others |
Lonapalene is a topically effective inhibitor of 5-lipoxygenase. | |||
T61211 | 5-LOX-IN-1 | Lipoxygenase | |
5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research. | |||
T12784 | RWJ 63556 | RWJ-63556 | Lipoxygenase , COX |
RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities. | |||
T22054 | BW 755C | Lipoxygenase | |
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. | |||
T27244 | Efletirizine | UCB 28754,UCB-28754,UCB28754 | Lipoxygenase , Histamine Receptor |
Efletirizine (UCB-28754) is a histamine receptor antagonist with inhibitory effects on the enzyme 5-lipoxygenase (5-LO), and is useful in the topical treatment of allergic diseases. | |||
T16817 | S-2474 | Lipoxygenase , COX | |
S-2474, an inhibitor of COX-2 and 5-lipoxygenase, has anti-inflammatory and neuroprotective activities and inhibits Abeta (25 - 35) and Abeta (1 - 40) induced cell death. | |||
T16503 | PF-4191834 | PF-04191834 | Lipoxygenase |
PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the ... | |||
T25737 | Linetastine | TMK 688,TMK-688,TMK688 | Lipoxygenase , LTR , Histamine Receptor |
Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers. | |||
TN2068 | Picrinine | Lipoxygenase | |
Picrinine is an akuammiline alkaloid extracted from the leaves of Alstonia scholaris. It exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase. | |||
TN1255 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid | Lipoxygenase | |
3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ). | |||
T8950 | CAY10698 | Lipoxygenase | |
CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM). |